ID   MGP_PRIGL               Reviewed;          30 AA.
AC   P83347;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Matrix Gla protein;
DE            Short=MGP;
DE   Flags: Fragment;
GN   Name=mgp;
OS   Prionace glauca (Blue shark) (Squalus glaucus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Carcharhinidae;
OC   Prionace.
OX   NCBI_TaxID=7815;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE.
RC   TISSUE=Cartilage;
RX   PubMed=14668966; DOI=10.1007/s00223-003-0079-4;
RA   Simes D.C., Williamson M.K., Schaff B.J., Gavaia P.J., Ingleton P.M.,
RA   Price P.A., Cancela M.L.;
RT   "Characterization of osteocalcin (BGP) and matrix Gla protein (MGP) fish
RT   specific antibodies: validation for immunodetection studies in lower
RT   vertebrates.";
RL   Calcif. Tissue Int. 74:170-180(2004).
CC   -!- FUNCTION: Associates with the organic matrix of calcified cartilage.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- PTM: Requires vitamin K-dependent gamma-carboxylation for its function.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the osteocalcin/matrix Gla protein family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P83347; -.
DR   GO; GO:0031012; C:extracellular matrix; TAS:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Chondrogenesis; Developmental protein; Differentiation;
KW   Direct protein sequencing; Gamma-carboxyglutamic acid; Phosphoprotein;
KW   Secreted.
FT   CHAIN           1..>30
FT                   /note="Matrix Gla protein"
FT                   /id="PRO_0000148913"
FT   MOD_RES         2
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P56620"
FT   MOD_RES         3
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P56620"
FT   MOD_RES         5
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P56620"
FT   NON_TER         30
FT                   /evidence="ECO:0000303|PubMed:14668966"
SQ   SEQUENCE   30 AA;  3419 MW;  9F3F16D4619EA193 CRC64;
     DSSESNEIDD VLFLGRRDAN SFMKYPQLGN