ID   MGR1_CANAL              Reviewed;         368 AA.
AC   Q5AHC2; A0A1D8PGV3;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Mitochondrial inner membrane i-AAA protease complex subunit MGR1;
GN   Name=MGR1; OrderedLocusNames=CAALFM_C203460CA;
GN   ORFNames=CaO19.8493, CaO19.874;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Component of the mitochondrial inner membrane i-AAA protease
CC       complex required for mitochondrial inner membrane protein turnover.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the mitochondrial inner membrane i-AAA protease
CC       complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MGR1 family. {ECO:0000305}.
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DR   EMBL; CP017624; AOW27382.1; -; Genomic_DNA.
DR   RefSeq; XP_720997.1; XM_715904.1.
DR   AlphaFoldDB; Q5AHC2; -.
DR   STRING; 237561.Q5AHC2; -.
DR   GeneID; 3637348; -.
DR   KEGG; cal:CAALFM_C203460CA; -.
DR   CGD; CAL0000195839; orf19.8493.
DR   VEuPathDB; FungiDB:C2_03460C_A; -.
DR   eggNOG; ENOG502QR67; Eukaryota.
DR   HOGENOM; CLU_871878_0_0_1; -.
DR   InParanoid; Q5AHC2; -.
DR   OrthoDB; 931061at2759; -.
DR   PRO; PR:Q5AHC2; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR013911; i-AAA_Mgr1.
DR   Pfam; PF08602; Mgr1; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..368
FT                   /note="Mitochondrial inner membrane i-AAA protease complex
FT                   subunit MGR1"
FT                   /id="PRO_0000324410"
FT   TOPO_DOM        1..72
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        73..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        90..124
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        125..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        142..368
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..48
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   368 AA;  41522 MW;  1316B2E75756DF09 CRC64;
     MGVYIPPPND KDDGDKKKQD TNSNTNQPTP PSSSSPSGST TIYIPNPASS IPRNPKVGLI
     WGPLTPASDN LPALYSMIGL QFVIGCGFFK YARTLSRLRP IGGFQQQPHA HMAPKLVRTG
     PIWKIALSVI TGSALSFGSG LELCRVTLPY DPWYDEAQHY RRMAVKNGDK PSSWFGAYRY
     YKPMDFKTWI DKVGDWIENV EKEIKIDDPA NFANLSLELG KNSNVINVQR QPQTSGGILN
     KLNNKGKYLE IYTKLNENNT KRWEKLLHED LNEVTELNKA PRLDLILEGK SDLINPEFTK
     SAIILGNHTM DDDDQFEMVW LNFEPWDELK LDTEYDIRLV PSYAGATEEI ENEDQESPLT
     DNVVAKQT