MGR1_PICST
ID MGR1_PICST Reviewed; 390 AA.
AC A3LN78;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 25-MAY-2022, entry version 52.
DE RecName: Full=Mitochondrial genome required protein 1;
GN Name=MGR1; ORFNames=PICST_40521;
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- FUNCTION: Component of the mitochondrial inner membrane i-AAA protease
CC complex required for mitochondrial inner membrane protein turnover.
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the mitochondrial inner membrane i-AAA protease
CC complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MGR1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABN64284.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CP000496; ABN64284.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001382313.1; XM_001382276.1.
DR AlphaFoldDB; A3LN78; -.
DR STRING; 4924.XP_001382313.1; -.
DR EnsemblFungi; ABN64284; ABN64284; PICST_40521.
DR GeneID; 4836728; -.
DR KEGG; pic:PICST_40521; -.
DR eggNOG; ENOG502QR67; Eukaryota.
DR HOGENOM; CLU_871878_0_0_1; -.
DR InParanoid; A3LN78; -.
DR OrthoDB; 931061at2759; -.
DR Proteomes; UP000002258; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR013911; i-AAA_Mgr1.
DR Pfam; PF08602; Mgr1; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..390
FT /note="Mitochondrial genome required protein 1"
FT /id="PRO_0000324415"
FT TOPO_DOM 1..87
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 88..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105..135
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 136..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..390
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 365..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 390 AA; 44461 MW; 3CC094AD4C27FB7F CRC64;
MGVYIPPPND NDSDKDKKKN KNNDNPNLNP EPSGDSKKVN NVIKGVSSTS PPGTTTYYIP
NPSTWIPHNP SAGLIWGPLT PSSDNRPALY GMVGLQFILG LGFFRAARQL YRPRTIVTSV
NSIPQHFTPK GSFWKASIPA LTGAVAIYGC GLELSRLMLA YDPWYEEAKY YRRVAIKNGD
KPSAWFGAYD YYKPMSTKAW IDKVGIWIKA TEHELSEKQE VLDVSIVQAN SSNPDDKGHV
EHVLIPVKKN NLMSQMNKKG KYVEIYNRLR ESNKSRYRTL LDTDLKDVQE LNKAERIDLI
LEGKSPYSNP EYTKPHIQLG NHHVDTDDEF EMVWLNFEPW DELKLETDYD IRLIPHWRWA
DSDNSEPELD AVEQQHNHSI SEAESSKELV
