ID   MGR1_YEAS7              Reviewed;         416 AA.
AC   A6ZTE8;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Mitochondrial inner membrane i-AAA protease complex subunit MGR1;
DE   AltName: Full=Mitochondrial genome-required protein 1;
GN   Name=MGR1; ORFNames=SCY_0541;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Component of the mitochondrial inner membrane i-AAA protease
CC       complex required for mitochondrial inner membrane protein turnover.
CC       Required for growth of cells lacking the mitochondrial genome (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the mitochondrial inner membrane i-AAA protease
CC       complex composed of at least MRG1 and YME1. Interacts directly with
CC       YME1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MGR1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFW02000089; EDN62087.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZTE8; -.
DR   EnsemblFungi; EDN62087; EDN62087; SCY_0541.
DR   HOGENOM; CLU_039216_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR013911; i-AAA_Mgr1.
DR   Pfam; PF08602; Mgr1; 2.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..416
FT                   /note="Mitochondrial inner membrane i-AAA protease complex
FT                   subunit MGR1"
FT                   /id="PRO_0000324416"
FT   TOPO_DOM        1..56
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        57..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..151
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        152..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        170..416
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          388..416
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        388..405
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   416 AA;  47028 MW;  CE31422CA794DD40 CRC64;
     MAVFTPPSGN SNSTDHTHTQ DDHDKDDNDI KKFYIRPSLG LKLWGPLVPA PDNLPGLYTL
     ITIQSAVGFF ALWRLRRLYK LPPPRRIATG THSDLSFGEL PSEMIVNGKT KIKKDIADFP
     TLNRFSTTHG DIVLAPPPII PRQSRFVSVR KLLWGLFGSL LLSQSLLELT RLNFLKYDPW
     CDEMKSVRDK KFFNNIVKYY HEGIDPTKIK VKDAMNGTPL STNIPEVKQS VALARAQVEA
     QNPIIKWFGP LEYKPMSFNE YLNRMEFHLD MFEFFQNKRN IRENSIELIN SISHNPQSSS
     TGLEGLSESK KLHLQNVEKR LHFLASSGDS ISAPVKRSST TLSRGVILPH DTKGPQDIDL
     DTIRSLYDPW MTLALETSLS IKFIPTTMPS HTKTPTSTDQ PLPGPTPKAL TNEKTH