MGR2_SCHPO
ID MGR2_SCHPO Reviewed; 120 AA.
AC P79082; Q8J2M7;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Protein mgr2;
GN Name=mgr2; ORFNames=SPBC27.06c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=PR745;
RX PubMed=9501991; DOI=10.1093/dnares/4.6.363;
RA Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.;
RT "Identification of open reading frames in Schizosaccharomyces pombe
RT cDNAs.";
RL DNA Res. 4:363-369(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=caf1-21;
RA Simonics T., Maraz A., Balla E.;
RT "Schizosaccharomyces pombe ATP sulfurylase.";
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RA Kohnosu A., Niwa O., Yano M., Saitoh S., Katayama T., Nagao K.,
RA Yanagida M.;
RT "S.pombe chromosome II cosmid 1228 sequence.";
RL Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Required for cell viability in cells lacking mitochondrial
CC DNA. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the MGR2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN32721.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAA12187.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; D89182; BAA13844.1; -; mRNA.
DR EMBL; AF421374; AAN32721.1; ALT_SEQ; Genomic_DNA.
DR EMBL; D83992; BAA12187.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CU329671; CAB89006.1; -; Genomic_DNA.
DR PIR; T42736; T42736.
DR RefSeq; NP_595661.1; NM_001021555.2.
DR AlphaFoldDB; P79082; -.
DR BioGRID; 276953; 105.
DR STRING; 4896.SPBC27.06c.1; -.
DR PaxDb; P79082; -.
DR EnsemblFungi; SPBC27.06c.1; SPBC27.06c.1:pep; SPBC27.06c.
DR GeneID; 2540425; -.
DR KEGG; spo:SPBC27.06c; -.
DR PomBase; SPBC27.06c; mgr2.
DR VEuPathDB; FungiDB:SPBC27.06c; -.
DR eggNOG; KOG4096; Eukaryota.
DR HOGENOM; CLU_142435_1_1_1; -.
DR InParanoid; P79082; -.
DR PhylomeDB; P79082; -.
DR PRO; PR:P79082; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; ISO:PomBase.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; ISO:PomBase.
DR GO; GO:0045039; P:protein insertion into mitochondrial inner membrane; ISO:PomBase.
DR InterPro; IPR018450; Romo1/Mgr2.
DR PANTHER; PTHR28525; PTHR28525; 1.
DR Pfam; PF10247; Romo1; 1.
DR SMART; SM01378; Romo1; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..120
FT /note="Protein mgr2"
FT /id="PRO_0000343158"
FT TOPO_DOM 1..15
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..49
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..120
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 120 AA; 12917 MW; 0053147F17E916BE CRC64;
MQSMQPSTVD KLKMGAIMGS AAGLGIGFLF GGVAVLRYGP GPRGFLRTLG QYMLTSAATF
GFFMSIGSVI RNEDIPLIQQ SGSHWNQRLL NENANSSRIF ALAMQQAKSS PRKSNEVAEC
