ID   MGR3L_YEAST             Reviewed;         463 AA.
AC   P36066; D6VX63;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   21-SEP-2011, sequence version 2.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Protein MRG3-like;
GN   OrderedLocusNames=YKL133C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8196765; DOI=10.1038/369371a0;
RA   Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V.,
RA   Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P.,
RA   Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L.,
RA   Daignan-Fornier B., del Rey F., Dion C., Domdey H., Duesterhoeft A.,
RA   Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H.,
RA   Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L.,
RA   Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M.,
RA   Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H.,
RA   Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J.,
RA   Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H.,
RA   Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J.,
RA   Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S.,
RA   Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F.,
RA   Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R.,
RA   Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W.,
RA   Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M.,
RA   Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C.,
RA   Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H.,
RA   Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L.,
RA   van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S.,
RA   von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M.,
RA   Becker I., Mewes H.-W.;
RT   "Complete DNA sequence of yeast chromosome XI.";
RL   Nature 369:371-378(1994).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 252.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MGR3 family. {ECO:0000305}.
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DR   EMBL; Z28133; CAA81974.1; -; Genomic_DNA.
DR   EMBL; BK006944; DAA09029.2; -; Genomic_DNA.
DR   PIR; S37962; S37962.
DR   RefSeq; NP_012789.2; NM_001179699.2.
DR   AlphaFoldDB; P36066; -.
DR   BioGRID; 34003; 27.
DR   DIP; DIP-2642N; -.
DR   IntAct; P36066; 1.
DR   MINT; P36066; -.
DR   STRING; 4932.YKL133C; -.
DR   MaxQB; P36066; -.
DR   PaxDb; P36066; -.
DR   PRIDE; P36066; -.
DR   EnsemblFungi; YKL133C_mRNA; YKL133C; YKL133C.
DR   GeneID; 853725; -.
DR   KEGG; sce:YKL133C; -.
DR   SGD; S000001616; YKL133C.
DR   VEuPathDB; FungiDB:YKL133C; -.
DR   eggNOG; ENOG502QU02; Eukaryota.
DR   GeneTree; ENSGT00940000176771; -.
DR   HOGENOM; CLU_039436_0_0_1; -.
DR   InParanoid; P36066; -.
DR   OMA; VAMESEM; -.
DR   BioCyc; YEAST:G3O-31912-MON; -.
DR   PRO; PR:P36066; -.
DR   Proteomes; UP000002311; Chromosome XI.
DR   RNAct; P36066; protein.
DR   GO; GO:0031942; C:i-AAA complex; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR   GO; GO:0051787; F:misfolded protein binding; IBA:GO_Central.
DR   GO; GO:0006515; P:protein quality control for misfolded or incompletely synthesized proteins; IBA:GO_Central.
DR   InterPro; IPR040201; Mrg3-like.
DR   PANTHER; PTHR28142; PTHR28142; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Repeat; TPR repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..463
FT                   /note="Protein MRG3-like"
FT                   /id="PRO_0000203149"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          84..118
FT                   /note="TPR 1"
FT   REPEAT          128..161
FT                   /note="TPR 2"
FT   REPEAT          358..389
FT                   /note="TPR 3"
FT   REPEAT          409..442
FT                   /note="TPR 4"
FT   CONFLICT        252
FT                   /note="Y -> I (in Ref. 1; CAA81974)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   463 AA;  54488 MW;  BC1D8E6527E9C257 CRC64;
     MWKYLHRSVK NEGTVERLTN LNLFTNHRFK FYSTLKEQSF WRIPFKRRSK LQKWVLSTGI
     VSFIAFNIWW VYWPHHTFPK PVAKILRKGL HSEIKKEGAN YQKSLEYYLE ALEECKAENV
     DLLSDEYTGI EIKIGEMYEK LHMYNDATAL YGDMLKKFYN ELSKTTDKST KRKFFLLKRD
     LQILVRFNEI NKDSETNATL LIMHLLLAQR EFLENSPEFK NVLSKSELLN NQQLDWKNFK
     GLPFIGKSKP DYQMHLNSKR KQELKIKEPE SEQCVFMKEL LTARDLYTRY CLNRSNLSGA
     LNSKITTLEW MLLADSPLDD ILLAQAELGS IFYLNSEKFE GSLYAIDNEP YKKSEPLELI
     RSRLQENQNS CLQYSADCYK SIISFANENQ YPKVAMESEM DQRILKALSL AHYGIGVINL
     HKGRLRASKK ELKKAIRISE MIRFNELIEE AQRELKKVDG TPI