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MGRA_STAAM
ID   MGRA_STAAM              Reviewed;         147 AA.
AC   Q99VT5;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=HTH-type transcriptional regulator MgrA;
GN   Name=mgrA; Synonyms=norR; OrderedLocusNames=SAV0686;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Regulatory protein involved in autolytic activity, multidrug
CC       resistance and virulence. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
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DR   EMBL; BA000017; BAB56848.1; -; Genomic_DNA.
DR   RefSeq; WP_001283444.1; NC_002758.2.
DR   AlphaFoldDB; Q99VT5; -.
DR   SMR; Q99VT5; -.
DR   World-2DPAGE; 0002:Q99VT5; -.
DR   PaxDb; Q99VT5; -.
DR   EnsemblBacteria; BAB56848; BAB56848; SAV0686.
DR   GeneID; 66838978; -.
DR   KEGG; sav:SAV0686; -.
DR   HOGENOM; CLU_083287_3_2_9; -.
DR   OMA; AHRMTKS; -.
DR   PhylomeDB; Q99VT5; -.
DR   BioCyc; SAUR158878:SAV_RS03770-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS01117; HTH_MARR_1; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Repressor; Transcription;
KW   Transcription regulation; Virulence.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..147
FT                   /note="HTH-type transcriptional regulator MgrA"
FT                   /id="PRO_0000054368"
FT   DOMAIN          8..139
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
FT   DNA_BIND        55..78
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
SQ   SEQUENCE   147 AA;  17089 MW;  F5EA62A451EF9FC8 CRC64;
     MSDQHNLKEQ LCFSLYNAQR QVNRYYSNKV FKKYNLTYPQ FLVLTILWDE SPVNVKKVVT
     ELALDTGTVS PLLKRMEQVD LIKRERSEVD QREVFIHLTD KSETIRPELS NASDKVASAS
     SLSQDEVKEL NRLLGKVIHA FDETKEK
 
 
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