ID   MGRA_STAAW              Reviewed;         147 AA.
AC   Q7A1J9;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=HTH-type transcriptional regulator MgrA;
GN   Name=mgrA; Synonyms=norR; OrderedLocusNames=MW0648;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- FUNCTION: Regulatory protein involved in autolytic activity, multidrug
CC       resistance and virulence. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
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DR   EMBL; BA000033; BAB94513.1; -; Genomic_DNA.
DR   RefSeq; WP_001283444.1; NC_003923.1.
DR   AlphaFoldDB; Q7A1J9; -.
DR   SMR; Q7A1J9; -.
DR   EnsemblBacteria; BAB94513; BAB94513; BAB94513.
DR   GeneID; 66838978; -.
DR   KEGG; sam:MW0648; -.
DR   HOGENOM; CLU_083287_3_2_9; -.
DR   OMA; AHRMTKS; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS01117; HTH_MARR_1; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Repressor; Transcription;
KW   Transcription regulation; Virulence.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..147
FT                   /note="HTH-type transcriptional regulator MgrA"
FT                   /id="PRO_0000054372"
FT   DOMAIN          8..139
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
FT   DNA_BIND        55..78
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
SQ   SEQUENCE   147 AA;  17089 MW;  F5EA62A451EF9FC8 CRC64;
     MSDQHNLKEQ LCFSLYNAQR QVNRYYSNKV FKKYNLTYPQ FLVLTILWDE SPVNVKKVVT
     ELALDTGTVS PLLKRMEQVD LIKRERSEVD QREVFIHLTD KSETIRPELS NASDKVASAS
     SLSQDEVKEL NRLLGKVIHA FDETKEK