ID   MGRB_ECOLC              Reviewed;          47 AA.
AC   B1J0R3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=PhoP/PhoQ regulator MgrB {ECO:0000255|HAMAP-Rule:MF_01596};
GN   Name=mgrB {ECO:0000255|HAMAP-Rule:MF_01596}; OrderedLocusNames=EcolC_1807;
OS   Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 /
OS   WDCM 00012 / Crooks).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=481805;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C.,
RA   Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Ingram L., Richardson P.;
RT   "Complete sequence of Escherichia coli C str. ATCC 8739.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: PhoP-regulated transcription is redox-sensitive, being
CC       activated when the periplasm becomes more reducing. MgrB acts between
CC       DsbA/DsbB and PhoP/PhoQ in this pathway. Represses PhoP/PhoQ signaling,
CC       possibly by binding to the periplasmic domain of PhoQ, altering its
CC       activity and that of downstream effector PhoP. {ECO:0000255|HAMAP-
CC       Rule:MF_01596}.
CC   -!- SUBUNIT: May form homooligomers. Probably interacts with the
CC       periplasmic domain of PhoQ. {ECO:0000255|HAMAP-Rule:MF_01596}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01596}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01596}.
CC   -!- SIMILARITY: Belongs to the MgrB family. {ECO:0000255|HAMAP-
CC       Rule:MF_01596}.
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DR   EMBL; CP000946; ACA77457.1; -; Genomic_DNA.
DR   RefSeq; WP_000714550.1; NZ_CP022959.1.
DR   AlphaFoldDB; B1J0R3; -.
DR   SMR; B1J0R3; -.
DR   GeneID; 66674285; -.
DR   KEGG; ecl:EcolC_1807; -.
DR   HOGENOM; CLU_208030_1_0_6; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070298; P:negative regulation of phosphorelay signal transduction system; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01596; MgrB; 1.
DR   InterPro; IPR020907; MgrB.
DR   Pfam; PF13998; MgrB; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..47
FT                   /note="PhoP/PhoQ regulator MgrB"
FT                   /id="PRO_1000088002"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01596"
SQ   SEQUENCE   47 AA;  5552 MW;  B1F03878D23CDDDE CRC64;
     MKKFRWVVLV VVVLACLLLW AQVFNMMCDQ DVQFFSGICA INQFIPW