ID   MGRB_SALHS              Reviewed;          47 AA.
AC   B4TKH1;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=PhoP/PhoQ regulator MgrB {ECO:0000255|HAMAP-Rule:MF_01596};
GN   Name=mgrB {ECO:0000255|HAMAP-Rule:MF_01596}; OrderedLocusNames=SeHA_C2041;
OS   Salmonella heidelberg (strain SL476).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=454169;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SL476;
RX   PubMed=21602358; DOI=10.1128/jb.00297-11;
RA   Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G.,
RA   Leclerc J.E., Ravel J., Cebula T.A.;
RT   "Comparative genomics of 28 Salmonella enterica isolates: evidence for
RT   CRISPR-mediated adaptive sublineage evolution.";
RL   J. Bacteriol. 193:3556-3568(2011).
CC   -!- FUNCTION: PhoP-regulated transcription is redox-sensitive, being
CC       activated when the periplasm becomes more reducing. MgrB acts between
CC       DsbA/DsbB and PhoP/PhoQ in this pathway. Represses PhoP/PhoQ signaling,
CC       possibly by binding to the periplasmic domain of PhoQ, altering its
CC       activity and that of downstream effector PhoP. {ECO:0000255|HAMAP-
CC       Rule:MF_01596}.
CC   -!- SUBUNIT: May form homooligomers. Probably interacts with the
CC       periplasmic domain of PhoQ. {ECO:0000255|HAMAP-Rule:MF_01596}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01596}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01596}.
CC   -!- SIMILARITY: Belongs to the MgrB family. {ECO:0000255|HAMAP-
CC       Rule:MF_01596}.
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DR   EMBL; CP001120; ACF67459.1; -; Genomic_DNA.
DR   RefSeq; WP_000714547.1; NC_011083.1.
DR   AlphaFoldDB; B4TKH1; -.
DR   GeneID; 66756315; -.
DR   KEGG; seh:SeHA_C2041; -.
DR   HOGENOM; CLU_208030_1_0_6; -.
DR   Proteomes; UP000001866; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070298; P:negative regulation of phosphorelay signal transduction system; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01596; MgrB; 1.
DR   InterPro; IPR020907; MgrB.
DR   Pfam; PF13998; MgrB; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..47
FT                   /note="PhoP/PhoQ regulator MgrB"
FT                   /id="PRO_1000201573"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01596"
SQ   SEQUENCE   47 AA;  5520 MW;  5A0469233478913F CRC64;
     MKKFRWVVLG IVVVVCLLLW AQVFNIMCDQ DVQFFSGICA INKFIPW