MGT4E_MOUSE
ID MGT4E_MOUSE Reviewed; 439 AA.
AC A6H684; B7ZNB9; E9Q5L0; Q8C1J0;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JUN-2014, sequence version 3.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E {ECO:0000305};
DE EC=2.4.1.-;
GN Name=Mgat4e {ECO:0000312|MGI:MGI:1918251};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Glycosyltransferase-like protein that may participate in the
CC transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues
CC of N-linked glycans. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A6H684-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6H684-2; Sequence=VSP_054935;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI45150.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC25485.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC25485.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK016512; BAC25485.1; ALT_SEQ; mRNA.
DR EMBL; AC122771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC145149; AAI45150.1; ALT_INIT; mRNA.
DR EMBL; BC145786; AAI45787.1; -; mRNA.
DR CCDS; CCDS48370.1; -. [A6H684-1]
DR RefSeq; NP_001138772.1; NM_001145300.2. [A6H684-1]
DR RefSeq; NP_001277944.1; NM_001291015.1. [A6H684-2]
DR AlphaFoldDB; A6H684; -.
DR CAZy; GT54; Glycosyltransferase Family 54.
DR PaxDb; A6H684; -.
DR PRIDE; A6H684; -.
DR ProteomicsDB; 295940; -. [A6H684-1]
DR ProteomicsDB; 295941; -. [A6H684-2]
DR DNASU; 71001; -.
DR Ensembl; ENSMUST00000052911; ENSMUSP00000125929; ENSMUSG00000046367. [A6H684-1]
DR Ensembl; ENSMUST00000172898; ENSMUSP00000133717; ENSMUSG00000046367. [A6H684-1]
DR GeneID; 71001; -.
DR KEGG; mmu:71001; -.
DR UCSC; uc007csd.3; mouse. [A6H684-1]
DR CTD; 71001; -.
DR MGI; MGI:1918251; Mgat4e.
DR VEuPathDB; HostDB:ENSMUSG00000046367; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000163751; -.
DR HOGENOM; CLU_027046_3_0_1; -.
DR InParanoid; A6H684; -.
DR OMA; RAYPRIT; -.
DR OrthoDB; 593094at2759; -.
DR PhylomeDB; A6H684; -.
DR TreeFam; TF324570; -.
DR UniPathway; UPA00378; -.
DR BioGRID-ORCS; 71001; 1 hit in 71 CRISPR screens.
DR PRO; PR:A6H684; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; A6H684; protein.
DR Bgee; ENSMUSG00000046367; Expressed in seminiferous tubule of testis and 13 other tissues.
DR ExpressionAtlas; A6H684; baseline and differential.
DR Genevisible; A6H684; MM.
DR GO; GO:0008375; F:acetylglucosaminyltransferase activity; IBA:GO_Central.
DR GO; GO:0006487; P:protein N-linked glycosylation; IBA:GO_Central.
DR InterPro; IPR006759; Glyco_transf_54.
DR PANTHER; PTHR12062; PTHR12062; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycosyltransferase; Reference proteome; Transferase.
FT CHAIN 1..439
FT /note="Alpha-1,3-mannosyl-glycoprotein 4-beta-N-
FT acetylglucosaminyltransferase-like protein MGAT4E"
FT /evidence="ECO:0000305"
FT /id="PRO_0000325757"
FT VAR_SEQ 1..82
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_054935"
FT CONFLICT 89
FT /note="L -> M (in Ref. 1; BAC25485)"
FT /evidence="ECO:0000305"
FT CONFLICT 139
FT /note="R -> Q (in Ref. 1; BAC25485)"
FT /evidence="ECO:0000305"
FT CONFLICT 145..146
FT /note="KQ -> QH (in Ref. 1; BAC25485)"
FT /evidence="ECO:0000305"
FT CONFLICT 159
FT /note="K -> Q (in Ref. 1; BAC25485)"
FT /evidence="ECO:0000305"
FT CONFLICT 165
FT /note="L -> F (in Ref. 1; BAC25485)"
FT /evidence="ECO:0000305"
FT CONFLICT 176..177
FT /note="NF -> TS (in Ref. 1; BAC25485)"
FT /evidence="ECO:0000305"
FT CONFLICT 208
FT /note="L -> S (in Ref. 1; BAC25485)"
FT /evidence="ECO:0000305"
FT CONFLICT 214
FT /note="P -> Q (in Ref. 1; BAC25485)"
FT /evidence="ECO:0000305"
FT CONFLICT 436..437
FT /note="Missing (in Ref. 3; AAI45150/AAI45787)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 439 AA; 49986 MW; CDE3D34BF83D4735 CRC64;
MEGGLRTGRL PKAPELSLQS FPSEWSWVWT YPLFHKLAAF ACHASQAWLT VGITSESREG
PNGLLDTLAS LYHTSSTSEQ KQMTVLVHLA DSDPTWLRRT IIRISSLYRS QILTGQLLLI
HAPPDAYPAV NDAQNKVSRG QIYSKQNVDH AFLMSFATKL STYFLLIEDN VFCAPNFVNH
IRSKVGYRKP NTWVLLEFSN MGFLGKLLHS RDLPLLAHFL LLFHKERPLN WLLLHFRTLL
GQQSSILCRP FLFYHRLTHL TFENKTLIGH EKDPPDPYTL SGTVYTDMRF SDTHSPQEAY
TLDESFFWSY NVTTGNYLTV ILNNPANLNR VQVRTGSITD GKYILEKGQV ELGYDPEGTP
PQCTSFTLLG RLVQGQMDQF ILESIGYKVS CVKLAVNANQ VGGLMIRHIY IWGENAKNRK
DVQIDNDDDD DDDDYDDDS
