ID   MGTA_CORGL              Reviewed;         413 AA.
AC   Q8NT41; Q6M7Q4;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=GDP-mannose-dependent alpha-mannosyltransferase;
DE            EC=2.4.1.-;
DE   AltName: Full=Guanosine diphosphomannose-dependent alpha-mannosyltransferase;
GN   Name=mgtA; OrderedLocusNames=Cgl0469, cg0554;
OS   Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 /
OS   JCM 1318 / LMG 3730 / NCIMB 10025).
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=196627;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC   10025;
RX   PubMed=12743753; DOI=10.1007/s00253-003-1328-1;
RA   Ikeda M., Nakagawa S.;
RT   "The Corynebacterium glutamicum genome: features and impacts on
RT   biotechnological processes.";
RL   Appl. Microbiol. Biotechnol. 62:99-109(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB
RC   10025;
RX   PubMed=12948626; DOI=10.1016/s0168-1656(03)00154-8;
RA   Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A.,
RA   Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A.,
RA   Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F.,
RA   Moeckel B., Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O.,
RA   Sahm H., Wendisch V.F., Wiegraebe I., Tauch A.;
RT   "The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its
RT   impact on the production of L-aspartate-derived amino acids and vitamins.";
RL   J. Biotechnol. 104:5-25(2003).
RN   [3]
RP   FUNCTION AS MANNOSYLTRANSFERASE, AND NOMENCLATURE.
RX   PubMed=17179146; DOI=10.1074/jbc.m608695200;
RA   Tatituri R.V., Illarionov P.A., Dover L.G., Nigou J., Gilleron M.,
RA   Hitchen P., Krumbach K., Morris H.R., Spencer N., Dell A., Eggeling L.,
RA   Besra G.S.;
RT   "Inactivation of Corynebacterium glutamicum NCgl0452 and the role of MgtA
RT   in the biosynthesis of a novel mannosylated glycolipid involved in
RT   lipomannan biosynthesis.";
RL   J. Biol. Chem. 282:4561-4572(2007).
RN   [4]
RP   FUNCTION IN MANGLCAGROAC2 BIOSYNTHESIS.
RX   PubMed=19395496; DOI=10.1128/jb.01729-08;
RA   Mishra A.K., Batt S., Krumbach K., Eggeling L., Besra G.S.;
RT   "Characterization of the Corynebacterium glutamicum deltapimB' deltamgtA
RT   double deletion mutant and the role of Mycobacterium tuberculosis
RT   orthologues Rv2188c and Rv0557 in glycolipid biosynthesis.";
RL   J. Bacteriol. 191:4465-4472(2009).
CC   -!- FUNCTION: Catalyzes the addition of a mannose residue from GDP-D-
CC       mannose to GlcAGroAc2 to generate 1,2-di-O-C16/C18:1-(alpha-D-
CC       mannopyranosyl)-(1-4)-(alpha-D-glucopyranosyluronic acid)-(1-3)-
CC       glycerol(ManGlcAGroAc2). {ECO:0000269|PubMed:17179146,
CC       ECO:0000269|PubMed:19395496}.
CC   -!- PATHWAY: Phospholipid metabolism; phosphatidylinositol metabolism.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase group 1 family.
CC       {ECO:0000305}.
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DR   EMBL; BA000036; BAB97862.1; -; Genomic_DNA.
DR   EMBL; BX927149; CAF19183.1; -; Genomic_DNA.
DR   RefSeq; NP_599714.1; NC_003450.3.
DR   AlphaFoldDB; Q8NT41; -.
DR   SMR; Q8NT41; -.
DR   STRING; 196627.cg0554; -.
DR   CAZy; GT4; Glycosyltransferase Family 4.
DR   KEGG; cgb:cg0554; -.
DR   KEGG; cgl:Cgl0469; -.
DR   PATRIC; fig|196627.13.peg.467; -.
DR   eggNOG; COG0438; Bacteria.
DR   eggNOG; COG0707; Bacteria.
DR   HOGENOM; CLU_009583_2_0_11; -.
DR   OMA; ERVDLWQ; -.
DR   UniPathway; UPA00949; -.
DR   Proteomes; UP000000582; Chromosome.
DR   GO; GO:0000030; F:mannosyltransferase activity; IDA:UniProtKB.
DR   GO; GO:0009247; P:glycolipid biosynthetic process; IDA:UniProtKB.
DR   GO; GO:0046488; P:phosphatidylinositol metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR028098; Glyco_trans_4-like_N.
DR   Pfam; PF13439; Glyco_transf_4; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
PE   1: Evidence at protein level;
KW   Glycosyltransferase; Lipid biosynthesis; Lipid metabolism;
KW   Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome;
KW   Transferase.
FT   CHAIN           1..413
FT                   /note="GDP-mannose-dependent alpha-mannosyltransferase"
FT                   /id="PRO_0000393730"
SQ   SEQUENCE   413 AA;  44919 MW;  3D5DBE9BFBFC6EB2 CRC64;
     MEIIRPMRVA IVAESFLPNV NGVTNSVLRV LEHLKANGHD ALVIAPGARD FEEEIGHYLG
     FEIVRVPTVR VPLIDSLPIG VPLPSVTSVL REYNPDIIHL ASPFVLGGAA AFAARQLRIP
     AIAIYQTDVA GFSQRYHLAP LATASWEWIK TVHNMCQRTL APSSMSIDEL RDHGINDIFH
     WARGVDSKRF HPGKRSVALR KSWDPSGAKK IVGFVGRLAS EKGVECLAGL SGRSDIQLVI
     VGDGPEAKYL QEMMPDAIFT GALGGEELAT TYASLDLFVH PGEFETFCQA IQEAQASGVP
     TIGPRAGGPI DLINEGVNGL LLDVVDFKET LPAAAEWILD DSRHSEMCAA AWEGVKDKTW
     EALCTQLLQH YADVIALSQR IPLTFFGPSA EVAKLPLWVA RALGVRTRIS IEA