MGTA_MYCS2
ID MGTA_MYCS2 Reviewed; 375 AA.
AC A0QRG8; I7F7L0;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=GDP-mannose-dependent alpha-mannosyltransferase;
DE EC=2.4.1.-;
DE AltName: Full=Guanosine diphosphomannose-dependent alpha-mannosyltransferase;
GN Name=mgtA; Synonyms=pimB; OrderedLocusNames=MSMEG_1113, MSMEI_1080;
OS Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS smegmatis).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=246196;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RA Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA Fraser C.M.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RX PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT mutations or sequencing errors?";
RL Genome Biol. 8:R20.1-R20.9(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700084 / mc(2)155;
RX PubMed=18955433; DOI=10.1101/gr.081901.108;
RA Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT and a new MS-based protocol.";
RL Genome Res. 19:128-135(2009).
CC -!- FUNCTION: Catalyzes the addition of a mannose residue from GDP-D-
CC mannose to GlcAGroAc2 to generate 1,2-di-O-C16/C18:1-(alpha-D-
CC mannopyranosyl)-(1-4)-(alpha-D-glucopyranosyluronic acid)-(1-3)-
CC glycerol(ManGlcAGroAc2). {ECO:0000250}.
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylinositol metabolism.
CC -!- SIMILARITY: Belongs to the glycosyltransferase group 1 family.
CC Glycosyltransferase 4 subfamily. {ECO:0000305}.
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DR EMBL; CP000480; ABK71357.1; -; Genomic_DNA.
DR EMBL; CP001663; AFP37560.1; -; Genomic_DNA.
DR RefSeq; WP_011727419.1; NZ_SIJM01000011.1.
DR RefSeq; YP_885506.1; NC_008596.1.
DR AlphaFoldDB; A0QRG8; -.
DR SMR; A0QRG8; -.
DR STRING; 246196.MSMEI_1080; -.
DR CAZy; GT4; Glycosyltransferase Family 4.
DR EnsemblBacteria; ABK71357; ABK71357; MSMEG_1113.
DR EnsemblBacteria; AFP37560; AFP37560; MSMEI_1080.
DR GeneID; 66732575; -.
DR KEGG; msg:MSMEI_1080; -.
DR KEGG; msm:MSMEG_1113; -.
DR PATRIC; fig|246196.19.peg.1101; -.
DR eggNOG; COG0438; Bacteria.
DR OMA; ERVDLWQ; -.
DR OrthoDB; 948440at2; -.
DR UniPathway; UPA00949; -.
DR Proteomes; UP000000757; Chromosome.
DR Proteomes; UP000006158; Chromosome.
DR GO; GO:0000030; F:mannosyltransferase activity; ISS:UniProtKB.
DR GO; GO:0009247; P:glycolipid biosynthetic process; ISS:UniProtKB.
DR GO; GO:0046488; P:phosphatidylinositol metabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR028098; Glyco_trans_4-like_N.
DR Pfam; PF13439; Glyco_transf_4; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase; Lipid biosynthesis; Lipid metabolism;
KW Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome;
KW Transferase; Virulence.
FT CHAIN 1..375
FT /note="GDP-mannose-dependent alpha-mannosyltransferase"
FT /id="PRO_0000393731"
SQ SEQUENCE 375 AA; 40565 MW; 62410854271FD7C4 CRC64;
MRVAIVAESF LPNVNGVTNS VLRVIDHLRR TGHEVLVIAP DTPRGQPPAD RIHDGVRVHR
VPSRMFPKIT SLPLGVPRPR MIGVLRGFDP DVVHLASPAL LGYGGLHAAR HLGVPSVAVF
QTDVAGFAES YGMGVASRAA WAWTRHLHSR ADRTLAPSTS AMENLAAHRI PRVHRWGRGV
DITGFVPSAR DEHLRRTWSP DGRPIVGFVG RLAPEKHVER LAVLAARDDL QLVIVGDGVD
RVKLQTVLPT AVFTGELRGA ALAAAYASMD VFVHPGEHET FCQTVQEAMA SGVPVIAPDA
GGPRDLVAPC RTGLLLDVDG FECALPAAVT HLIAERRRYG IAARRSVLAR TWPVVCDELI
GHYEAVLGRR SLRAA