ID   MGTA_MYCTO              Reviewed;         378 AA.
AC   P9WMY4; L0T409; O06423; Q7BTG3; Q8VKJ0;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=GDP-mannose-dependent alpha-mannosyltransferase;
DE            EC=2.4.1.-;
DE   AltName: Full=Guanosine diphosphomannose-dependent alpha-mannosyltransferase;
GN   Name=mgtA; Synonyms=pimB; OrderedLocusNames=MT0583;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Catalyzes the addition of a mannose residue from GDP-D-
CC       mannose to GlcAGroAc2 to generate 1,2-di-O-C16/C18:1-(alpha-D-
CC       mannopyranosyl)-(1-4)-(alpha-D-glucopyranosyluronic acid)-(1-3)-
CC       glycerol(ManGlcAGroAc2). {ECO:0000250}.
CC   -!- PATHWAY: Phospholipid metabolism; phosphatidylinositol metabolism.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase group 1 family.
CC       Glycosyltransferase 4 subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK44806.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK44806.1; ALT_INIT; Genomic_DNA.
DR   PIR; H70548; H70548.
DR   RefSeq; WP_003900963.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WMY4; -.
DR   SMR; P9WMY4; -.
DR   CAZy; GT4; Glycosyltransferase Family 4.
DR   EnsemblBacteria; AAK44806; AAK44806; MT0583.
DR   KEGG; mtc:MT0583; -.
DR   PATRIC; fig|83331.31.peg.614; -.
DR   HOGENOM; CLU_009583_2_0_11; -.
DR   UniPathway; UPA00949; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046488; P:phosphatidylinositol metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR028098; Glyco_trans_4-like_N.
DR   Pfam; PF13439; Glyco_transf_4; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Lipid biosynthesis; Lipid metabolism;
KW   Phospholipid biosynthesis; Phospholipid metabolism; Transferase; Virulence.
FT   CHAIN           1..378
FT                   /note="GDP-mannose-dependent alpha-mannosyltransferase"
FT                   /id="PRO_0000427221"
SQ   SEQUENCE   378 AA;  41238 MW;  E1E5524A88A52D65 CRC64;
     MCGVRVAIVA ESFLPQVNGV SNSVVKVLEH LRRTGHEALV IAPDTPPGED RAERLHDGVR
     VHRVPSRMFP KVTTLPLGVP TFRMLRALRG FDPDVVHLAS PALLGYGGLH AARRLGVPTV
     AVYQTDVPGF ASSYGIPMTA RAAWAWFRHL HRLADRTLAP STATMESLIA QGIPRVHRWA
     RGVDVQRFAP SARNEVLRRR WSPDGKPIVG FVGRLAPEKH VDRLTGLAAS GAVRLVIVGD
     GIDRARLQSA MPTAVFTGAR YGKELAEAYA SMDVFVHSGE HETFCQVVQE ALASGLPVIA
     PDAGGPRDLI TPHRTGLLLP VGEFEHRLPD AVAHLVHERQ RYALAARRSV LGRSWPVVCD
     ELLGHYEAVR GRRTTQAA