ID   MGTC_BRUAB              Reviewed;         238 AA.
AC   Q57A43;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Protein MgtC;
GN   Name=mgtC; OrderedLocusNames=BruAb2_0040;
OS   Brucella abortus biovar 1 (strain 9-941).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=262698;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=9-941;
RX   PubMed=15805518; DOI=10.1128/jb.187.8.2715-2726.2005;
RA   Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z.,
RA   Li L.-L., Kapur V., Alt D.P., Olsen S.C.;
RT   "Completion of the genome sequence of Brucella abortus and comparison to
RT   the highly similar genomes of Brucella melitensis and Brucella suis.";
RL   J. Bacteriol. 187:2715-2726(2005).
CC   -!- FUNCTION: Virulence factor required for growth in low Mg(2+) medium and
CC       for intramacrophage survival. May be involved in regulating membrane
CC       potential by activating Na(+)/K(+)-ATPase (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MgtC/SapB family. {ECO:0000305}.
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DR   EMBL; AE017224; AAX75491.1; -; Genomic_DNA.
DR   RefSeq; WP_002966539.1; NC_006933.1.
DR   AlphaFoldDB; Q57A43; -.
DR   SMR; Q57A43; -.
DR   PRIDE; Q57A43; -.
DR   EnsemblBacteria; AAX75491; AAX75491; BruAb2_0040.
DR   GeneID; 45053140; -.
DR   GeneID; 55591780; -.
DR   KEGG; bmb:BruAb2_0040; -.
DR   HOGENOM; CLU_079292_0_0_5; -.
DR   OMA; RAQIVQH; -.
DR   Proteomes; UP000000540; Chromosome II.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR003416; MgtC/SapB/SrpB/YhiD_fam.
DR   PANTHER; PTHR33778; PTHR33778; 1.
DR   Pfam; PF02308; MgtC; 1.
DR   PRINTS; PR01837; MGTCSAPBPROT.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Virulence.
FT   CHAIN           1..238
FT                   /note="Protein MgtC"
FT                   /id="PRO_0000250523"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   238 AA;  25357 MW;  2D1E20FA7069CE60 CRC64;
     MVWKPLAHTA ACLAGAFLLG GLIGFERQFR HRLAGLRTNT LVAVGAATFV VFSSLVSGDS
     SPTRVAAQIV SGIGFLGAGI IFKEGFNVRG LNTAATLWCS AAVGVLCGAG LISHAAVATV
     FIIAVNALLR PLVQVLEFQA MRRGAFQPTY AIDIICHGDA EAQVRALLLR DIGDHLHIHE
     LESSNIEGTN RVEVSATVRA DQRQDRLLEQ IVGHLSLEPR ITSARWRIED DSGGLSGL