ID   MGTC_BRUSU              Reviewed;         238 AA.
AC   Q8FXM5; G0KEN8;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Protein MgtC;
GN   Name=mgtC; OrderedLocusNames=BRA0040, BS1330_II0040;
OS   Brucella suis biovar 1 (strain 1330).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=204722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=12271122; DOI=10.1073/pnas.192319099;
RA   Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA   Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA   Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA   Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E.,
RA   Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L.,
RA   Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
RT   "The Brucella suis genome reveals fundamental similarities between animal
RT   and plant pathogens and symbionts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=22038969; DOI=10.1128/jb.06181-11;
RA   Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.;
RT   "Revised genome sequence of Brucella suis 1330.";
RL   J. Bacteriol. 193:6410-6410(2011).
RN   [3]
RP   FUNCTION.
RC   STRAIN=1330;
RX   PubMed=15845525; DOI=10.1128/iai.73.5.3160-3163.2005;
RA   Lavigne J.-P., O'Callaghan D., Blanc-Potard A.-B.;
RT   "Requirement of MgtC for Brucella suis intramacrophage growth: a potential
RT   mechanism shared by Salmonella enterica and Mycobacterium tuberculosis for
RT   adaptation to a low-Mg2+ environment.";
RL   Infect. Immun. 73:3160-3163(2005).
CC   -!- FUNCTION: Virulence factor required for growth in low Mg(2+) medium and
CC       for intramacrophage survival. May be involved in regulating membrane
CC       potential by activating Na(+)/K(+)-ATPase (By similarity).
CC       {ECO:0000250, ECO:0000269|PubMed:15845525}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MgtC/SapB family. {ECO:0000305}.
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DR   EMBL; AE014292; AAN33252.1; -; Genomic_DNA.
DR   EMBL; CP002998; AEM19532.1; -; Genomic_DNA.
DR   RefSeq; WP_002966539.1; NZ_KN046805.1.
DR   AlphaFoldDB; Q8FXM5; -.
DR   SMR; Q8FXM5; -.
DR   EnsemblBacteria; AEM19532; AEM19532; BS1330_II0040.
DR   GeneID; 45053140; -.
DR   GeneID; 55591780; -.
DR   KEGG; bms:BRA0040; -.
DR   KEGG; bsi:BS1330_II0040; -.
DR   PATRIC; fig|204722.21.peg.2334; -.
DR   HOGENOM; CLU_079292_0_0_5; -.
DR   OMA; RAQIVQH; -.
DR   PhylomeDB; Q8FXM5; -.
DR   Proteomes; UP000007104; Chromosome II.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR003416; MgtC/SapB/SrpB/YhiD_fam.
DR   PANTHER; PTHR33778; PTHR33778; 1.
DR   Pfam; PF02308; MgtC; 1.
DR   PRINTS; PR01837; MGTCSAPBPROT.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Virulence.
FT   CHAIN           1..238
FT                   /note="Protein MgtC"
FT                   /id="PRO_0000250526"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   238 AA;  25357 MW;  2D1E20FA7069CE60 CRC64;
     MVWKPLAHTA ACLAGAFLLG GLIGFERQFR HRLAGLRTNT LVAVGAATFV VFSSLVSGDS
     SPTRVAAQIV SGIGFLGAGI IFKEGFNVRG LNTAATLWCS AAVGVLCGAG LISHAAVATV
     FIIAVNALLR PLVQVLEFQA MRRGAFQPTY AIDIICHGDA EAQVRALLLR DIGDHLHIHE
     LESSNIEGTN RVEVSATVRA DQRQDRLLEQ IVGHLSLEPR ITSARWRIED DSGGLSGL