ID   MGTC_SALPA              Reviewed;         231 AA.
AC   Q5PC53;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Protein MgtC;
GN   Name=mgtC; OrderedLocusNames=SPA3614;
OS   Salmonella paratyphi A (strain ATCC 9150 / SARB42).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=295319;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 9150 / SARB42;
RX   PubMed=15531882; DOI=10.1038/ng1470;
RA   McClelland M., Sanderson K.E., Clifton S.W., Latreille P., Porwollik S.,
RA   Sabo A., Meyer R., Bieri T., Ozersky P., McLellan M., Harkins C.R.,
RA   Wang C., Nguyen C., Berghoff A., Elliott G., Kohlberg S., Strong C., Du F.,
RA   Carter J., Kremizki C., Layman D., Leonard S., Sun H., Fulton L., Nash W.,
RA   Miner T., Minx P., Delehaunty K., Fronick C., Magrini V., Nhan M.,
RA   Warren W., Florea L., Spieth J., Wilson R.K.;
RT   "Comparison of genome degradation in Paratyphi A and Typhi, human-
RT   restricted serovars of Salmonella enterica that cause typhoid.";
RL   Nat. Genet. 36:1268-1274(2004).
CC   -!- FUNCTION: Virulence factor required for growth in low Mg(2+) medium and
CC       for intramacrophage survival. May be involved in regulating membrane
CC       potential by activating Na(+)/K(+)-ATPase (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MgtC/SapB family. {ECO:0000305}.
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DR   EMBL; CP000026; AAV79412.1; -; Genomic_DNA.
DR   RefSeq; WP_000392696.1; NC_006511.1.
DR   AlphaFoldDB; Q5PC53; -.
DR   SMR; Q5PC53; -.
DR   EnsemblBacteria; AAV79412; AAV79412; SPA3614.
DR   KEGG; spt:SPA3614; -.
DR   HOGENOM; CLU_079292_0_0_6; -.
DR   OMA; RAQIVQH; -.
DR   Proteomes; UP000008185; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR003416; MgtC/SapB/SrpB/YhiD_fam.
DR   PANTHER; PTHR33778; PTHR33778; 1.
DR   Pfam; PF02308; MgtC; 1.
DR   PRINTS; PR01837; MGTCSAPBPROT.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Virulence.
FT   CHAIN           1..231
FT                   /note="Protein MgtC"
FT                   /id="PRO_0000250528"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   231 AA;  25081 MW;  398DCC35A04E30FC CRC64;
     MEERMLMFPY ILNLLAAMLL GALIGAERQW RQRMAGLRTN ALVATGAAVF ILSSMTTSPD
     SPGRIAAQIV SGIGFLGAGV IMREGMNVRG LNTAATLWCS AGIGVLCGLG QFKNALAATI
     IILCANILLR EAAQRINQLP VSAEAEKRYI LKVTCNKEDE SAVRQWLLNI VKEAAICLQG
     LGSVPAQEQG YKEIRAELVG HADYRKTREL IISRIGDNDN ITAIHWCIDS Q