ID   MGTC_SALT1              Reviewed;         231 AA.
AC   D0ZLQ7; P22037;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Protein MgtC;
GN   Name=mgtC; OrderedLocusNames=STM14_4538;
OS   Salmonella typhimurium (strain 14028s / SGSC 2262).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=588858;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 14028s / SGSG 2262;
RX   PubMed=9922266; DOI=10.1128/jb.181.3.998-1004.1999;
RA   Blanc-Potard A.-B., Solomon F., Kayser J., Groisman E.A.;
RT   "The SPI-3 pathogenicity island of Salmonella enterica.";
RL   J. Bacteriol. 181:998-1004(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=14028s / SGSC 2262;
RX   PubMed=19897643; DOI=10.1128/jb.01233-09;
RA   Jarvik T., Smillie C., Groisman E.A., Ochman H.;
RT   "Short-term signatures of evolutionary change in the Salmonella enterica
RT   serovar typhimurium 14028 genome.";
RL   J. Bacteriol. 192:560-567(2010).
RN   [3]
RP   FUNCTION, AND INDUCTION.
RC   STRAIN=ATCC 14028s / SGSG 2262;
RX   PubMed=9311997; DOI=10.1093/emboj/16.17.5376;
RA   Blanc-Potard A.-B., Groisman E.A.;
RT   "The Salmonella selC locus contains a pathogenicity island mediating
RT   intramacrophage survival.";
RL   EMBO J. 16:5376-5385(1997).
RN   [4]
RP   FUNCTION, AND INDUCTION.
RC   STRAIN=ATCC 14028s / SGSG 2262;
RX   PubMed=9673265; DOI=10.1128/iai.66.8.3802-3809.1998;
RA   Moncrief M.B.C., Maguire M.E.;
RT   "Magnesium and the role of MgtC in growth of Salmonella typhimurium.";
RL   Infect. Immun. 66:3802-3809(1998).
CC   -!- FUNCTION: Virulence factor required for growth in low Mg(2+) medium and
CC       for intramacrophage survival. May be involved in regulating membrane
CC       potential by activating Na(+)/K(+)-ATPase. {ECO:0000269|PubMed:9311997,
CC       ECO:0000269|PubMed:9673265}.
CC   -!- INTERACTION:
CC       D0ZLQ7; A0A0F6B941: atpB; NbExp=5; IntAct=EBI-8772647, EBI-8772730;
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- INDUCTION: Part of the mgtC/mgtB operon. Induced by low extracellular
CC       levels of Mg(2+). Transcriptionally regulated by extracellular
CC       magnesium via the two-component regulatory system PhoQ/PhoP.
CC       {ECO:0000269|PubMed:9311997, ECO:0000269|PubMed:9673265}.
CC   -!- SIMILARITY: Belongs to the MgtC/SapB family. {ECO:0000305}.
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DR   EMBL; AF106566; AAD16960.1; -; Genomic_DNA.
DR   EMBL; CP001363; ACY90919.1; -; Genomic_DNA.
DR   RefSeq; WP_000392694.1; NZ_CP043402.1.
DR   AlphaFoldDB; D0ZLQ7; -.
DR   SMR; D0ZLQ7; -.
DR   IntAct; D0ZLQ7; 7.
DR   EnsemblBacteria; ACY90919; ACY90919; STM14_4538.
DR   KEGG; seo:STM14_4538; -.
DR   PATRIC; fig|588858.6.peg.4138; -.
DR   HOGENOM; CLU_079292_0_0_6; -.
DR   OMA; RAQIVQH; -.
DR   BioCyc; SENT588858:STM14_RS19885-MON; -.
DR   PHI-base; PHI:3668; -.
DR   PHI-base; PHI:4693; -.
DR   PHI-base; PHI:4698; -.
DR   Proteomes; UP000002695; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR003416; MgtC/SapB/SrpB/YhiD_fam.
DR   PANTHER; PTHR33778; PTHR33778; 1.
DR   Pfam; PF02308; MgtC; 1.
DR   PRINTS; PR01837; MGTCSAPBPROT.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Virulence.
FT   CHAIN           1..231
FT                   /note="Protein MgtC"
FT                   /id="PRO_0000403462"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   231 AA;  25065 MW;  247DB4DCC3BFDB3D CRC64;
     MEERMLMFPY ILNLLAAMLL GALIGAERQW RQRMAGLRTN ALVATGAAVF ILSSMTTSPD
     SPGRIAAQIV SGIGFLGAGV IMREGMNVRG LNTAATLWCS AGIGVLCGLG QFKNALAATI
     IILCANILLR EAAQRINQLP ISAEGEKRYI LKVTCNKEDE SAVRQWLLNI VKEAAICLQG
     LGSVPAQEQG YKEIRAELVG HADYRKTREL IISRIGDNDN ITAIHWSIDS Q