ID   MGTC_SALTI              Reviewed;         231 AA.
AC   Q8Z2J2; Q7C6D0;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Protein MgtC;
GN   Name=mgtC; OrderedLocusNames=STY4022, t3754;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Virulence factor required for growth in low Mg(2+) medium and
CC       for intramacrophage survival. May be involved in regulating membrane
CC       potential by activating Na(+)/K(+)-ATPase (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MgtC/SapB family. {ECO:0000305}.
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DR   EMBL; AL513382; CAD03230.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO71244.1; -; Genomic_DNA.
DR   RefSeq; NP_458170.1; NC_003198.1.
DR   RefSeq; WP_000392697.1; NZ_WSUR01000001.1.
DR   AlphaFoldDB; Q8Z2J2; -.
DR   SMR; Q8Z2J2; -.
DR   STRING; 220341.16504858; -.
DR   EnsemblBacteria; AAO71244; AAO71244; t3754.
DR   KEGG; stt:t3754; -.
DR   KEGG; sty:STY4022; -.
DR   PATRIC; fig|220341.7.peg.4106; -.
DR   eggNOG; COG1285; Bacteria.
DR   HOGENOM; CLU_079292_0_0_6; -.
DR   OMA; RAQIVQH; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR003416; MgtC/SapB/SrpB/YhiD_fam.
DR   PANTHER; PTHR33778; PTHR33778; 1.
DR   Pfam; PF02308; MgtC; 1.
DR   PRINTS; PR01837; MGTCSAPBPROT.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Virulence.
FT   CHAIN           1..231
FT                   /note="Protein MgtC"
FT                   /id="PRO_0000250529"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   231 AA;  25065 MW;  398DCC35BB4E30FC CRC64;
     MEERMLMFPY ILNLLAAMLL GALIGAERQW RQRMAGLRTN ALVATGAAVF ILSSMTTSPD
     SPGRIAAQIV SGIGFLGAGV IMREGMNVRG LNTAATLWCS AGIGVLCGLG QFKNALAATI
     IILCANILLR EAAQRINQLP VSAEAEKRYI LKVTCNKEDE SAVRQWLLNI VKEAAICLQG
     LGSVPAQEQG YKEIRAELVG HADYRKTREL IISRIGDNDN ITAIHWSIDS Q