ARLY_CORGB
ID ARLY_CORGB Reviewed; 477 AA.
AC A4QDZ5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN Name=argH {ECO:0000255|HAMAP-Rule:MF_00006}; OrderedLocusNames=cgR_1464;
OS Corynebacterium glutamicum (strain R).
OC Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC Corynebacterium.
OX NCBI_TaxID=340322;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R;
RX PubMed=17379713; DOI=10.1099/mic.0.2006/003657-0;
RA Yukawa H., Omumasaba C.A., Nonaka H., Kos P., Okai N., Suzuki N., Suda M.,
RA Tsuge Y., Watanabe J., Ikeda Y., Vertes A.A., Inui M.;
RT "Comparative analysis of the Corynebacterium glutamicum group and complete
RT genome sequence of strain R.";
RL Microbiology 153:1042-1058(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00006};
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC Rule:MF_00006}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR EMBL; AP009044; BAF54455.1; -; Genomic_DNA.
DR RefSeq; WP_003858676.1; NC_009342.1.
DR AlphaFoldDB; A4QDZ5; -.
DR SMR; A4QDZ5; -.
DR EnsemblBacteria; BAF54455; BAF54455; cgR_1464.
DR GeneID; 58310587; -.
DR KEGG; cgt:cgR_1464; -.
DR HOGENOM; CLU_027272_2_2_11; -.
DR OMA; KKNPDVF; -.
DR PhylomeDB; A4QDZ5; -.
DR UniPathway; UPA00068; UER00114.
DR Proteomes; UP000006698; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR CDD; cd01359; Argininosuccinate_lyase; 1.
DR Gene3D; 1.10.275.10; -; 1.
DR HAMAP; MF_00006; Arg_succ_lyase; 1.
DR InterPro; IPR029419; Arg_succ_lyase_C.
DR InterPro; IPR009049; Argininosuccinate_lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR PANTHER; PTHR43814; PTHR43814; 1.
DR Pfam; PF14698; ASL_C2; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; SSF48557; 1.
DR TIGRFAMs; TIGR00838; argH; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase.
FT CHAIN 1..477
FT /note="Argininosuccinate lyase"
FT /id="PRO_1000000473"
SQ SEQUENCE 477 AA; 51084 MW; DA7C38B821194891 CRC64;
MEQHGTNEGA LWGGRFSGGP SEAMFALSVS THFDWVLAPY DVLASKAHAK VLHQAELLSD
EDLATMLAGL DQLGKDVADG AFGPLPSDED VHGAMERGLI DRVGPEVGGR LRAGRSRNDQ
VATLFRMWVR DAVRDIALGT TELVDALSAQ AKAHADAIMP GKTHFQAAQP VLLAHQLLAH
AQPLLRDIDR IRDLDKRLAV SPYGSGALAG SSLKLNPEAI AEELGFDSAA DNSIDATSSR
DFASETAFVL AQLAVDMSRL AEEIIAWCTP EFGYITLSDS WSTGSSIMPQ KKNPDVAELT
RGKSGRLIGN LTGLLATLKA QPLAYNRDLQ EDKEPIVDSV AQLNLLLPAM TGLVSTLTFN
TERMRELAPA GFTLATDLAE WMVRQGVPFR EAHEASGACV RIAESRGVDL IDLTDEELSG
VDARLTPEVR EVLTIDGAVA SRATRGGTAG VRVAEQRARV DAASTAHAEW ARAGVRR
