MGTC_SALTY
ID MGTC_SALTY Reviewed; 231 AA.
AC P0CI70; P22037;
DT 11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 1.
DT 03-AUG-2022, entry version 54.
DE RecName: Full=Protein MgtC;
GN Name=mgtC; OrderedLocusNames=STM3764;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], DISRUPTION PHENOTYPE, AND PROBABLE
RP OPERON STRUCTURE.
RC STRAIN=LT2;
RX PubMed=1824701; DOI=10.1016/s0021-9258(17)35246-8;
RA Snavely M.D., Miller C.G., Maguire M.E.;
RT "The mgtB Mg2+ transport locus of Salmonella typhimurium encodes a P-type
RT ATPase.";
RL J. Biol. Chem. 266:815-823(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [3]
RP INDUCTION, DISRUPTION PHENOTYPE, AND OPERON STRUCTURE.
RC STRAIN=LT2;
RX PubMed=7751273; DOI=10.1128/jb.177.10.2654-2662.1995;
RA Tao T., Snavely M.D., Farr S.G., Maguire M.E.;
RT "Magnesium transport in Salmonella typhimurium: mgtA encodes a P-type
RT ATPase and is regulated by Mg2+ in a manner similar to that of the mgtB P-
RT type ATPase.";
RL J. Bacteriol. 177:2654-2662(1995).
RN [4]
RP FUNCTION, AND INDUCTION.
RC STRAIN=LT2;
RX PubMed=9673265; DOI=10.1128/iai.66.8.3802-3809.1998;
RA Moncrief M.B.C., Maguire M.E.;
RT "Magnesium and the role of MgtC in growth of Salmonella typhimurium.";
RL Infect. Immun. 66:3802-3809(1998).
RN [5]
RP FUNCTION.
RC STRAIN=SL1344;
RX PubMed=16855249; DOI=10.1128/jb.00296-06;
RA Guenzel D., Kucharski L.M., Kehres D.G., Romero M.F., Maguire M.E.;
RT "The MgtC virulence factor of Salmonella enterica serovar Typhimurium
RT activates Na(+),K(+)-ATPase.";
RL J. Bacteriol. 188:5586-5594(2006).
CC -!- FUNCTION: Virulence factor required for growth in low Mg(2+) medium and
CC for intramacrophage survival. May be involved in regulating membrane
CC potential by activating Na(+)/K(+)-ATPase.
CC {ECO:0000269|PubMed:16855249, ECO:0000269|PubMed:9673265}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- INDUCTION: Part of the mgtC/mgtB operon. Induced by low extracellular
CC levels of Mg(2+). Transcriptionally regulated by extracellular
CC magnesium via the two-component regulatory system PhoQ/PhoP.
CC {ECO:0000269|PubMed:7751273, ECO:0000269|PubMed:9673265}.
CC -!- DISRUPTION PHENOTYPE: Not required for Mg(2+) influx by MgtB.
CC {ECO:0000269|PubMed:1824701, ECO:0000269|PubMed:7751273}.
CC -!- SIMILARITY: Belongs to the MgtC/SapB family. {ECO:0000305}.
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DR EMBL; M57715; AAA72083.1; -; Unassigned_DNA.
DR EMBL; AE006468; AAL22622.1; -; Genomic_DNA.
DR PIR; A39083; A39083.
DR RefSeq; NP_462663.1; NC_003197.2.
DR RefSeq; WP_000392694.1; NC_003197.2.
DR AlphaFoldDB; P0CI70; -.
DR SMR; P0CI70; -.
DR STRING; 99287.STM3764; -.
DR PaxDb; P0CI70; -.
DR EnsemblBacteria; AAL22622; AAL22622; STM3764.
DR GeneID; 1255288; -.
DR KEGG; stm:STM3764; -.
DR PATRIC; fig|99287.12.peg.3983; -.
DR HOGENOM; CLU_079292_0_0_6; -.
DR OMA; RAQIVQH; -.
DR PhylomeDB; P0CI70; -.
DR BioCyc; SENT99287:STM3764-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR003416; MgtC/SapB/SrpB/YhiD_fam.
DR PANTHER; PTHR33778; PTHR33778; 1.
DR Pfam; PF02308; MgtC; 1.
DR PRINTS; PR01837; MGTCSAPBPROT.
PE 2: Evidence at transcript level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Virulence.
FT CHAIN 1..231
FT /note="Protein MgtC"
FT /id="PRO_0000202029"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 231 AA; 25065 MW; 247DB4DCC3BFDB3D CRC64;
MEERMLMFPY ILNLLAAMLL GALIGAERQW RQRMAGLRTN ALVATGAAVF ILSSMTTSPD
SPGRIAAQIV SGIGFLGAGV IMREGMNVRG LNTAATLWCS AGIGVLCGLG QFKNALAATI
IILCANILLR EAAQRINQLP ISAEGEKRYI LKVTCNKEDE SAVRQWLLNI VKEAAICLQG
LGSVPAQEQG YKEIRAELVG HADYRKTREL IISRIGDNDN ITAIHWSIDS Q
