MGTE_BACSU
ID MGTE_BACSU Reviewed; 451 AA.
AC O34442; Q796L4;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Magnesium transporter MgtE;
GN Name=mgtE; Synonyms=ykoK; OrderedLocusNames=BSU13300;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RA Devine K.M.;
RT "Sequence of the Bacillus subtilis genome between xlyA and ykoR.";
RL Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
CC -!- FUNCTION: Acts as a magnesium transporter. {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SLC41A transporter family. {ECO:0000305}.
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DR EMBL; AJ002571; CAA05608.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB13187.1; -; Genomic_DNA.
DR PIR; G69859; G69859.
DR RefSeq; NP_389213.1; NC_000964.3.
DR RefSeq; WP_003232543.1; NZ_JNCM01000035.1.
DR AlphaFoldDB; O34442; -.
DR SMR; O34442; -.
DR STRING; 224308.BSU13300; -.
DR TCDB; 1.A.26.1.3; the mg(2+) transporter-e (mgte) family.
DR PaxDb; O34442; -.
DR PRIDE; O34442; -.
DR EnsemblBacteria; CAB13187; CAB13187; BSU_13300.
DR GeneID; 936439; -.
DR KEGG; bsu:BSU13300; -.
DR PATRIC; fig|224308.179.peg.1445; -.
DR eggNOG; COG2239; Bacteria.
DR InParanoid; O34442; -.
DR OMA; TMTVAVR; -.
DR PhylomeDB; O34442; -.
DR BioCyc; BSUB:BSU13300-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.357.20; -; 1.
DR Gene3D; 1.25.60.10; -; 1.
DR Gene3D; 3.10.580.10; -; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR006668; Mg_transptr_MgtE_intracell_dom.
DR InterPro; IPR038076; MgtE_N_sf.
DR InterPro; IPR006669; MgtE_transporter.
DR InterPro; IPR006667; SLC41_membr_dom.
DR InterPro; IPR036739; SLC41_membr_dom_sf.
DR PANTHER; PTHR43773; PTHR43773; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF01769; MgtE; 1.
DR Pfam; PF03448; MgtE_N; 1.
DR SMART; SM00116; CBS; 2.
DR SMART; SM00924; MgtE_N; 1.
DR SUPFAM; SSF161093; SSF161093; 1.
DR SUPFAM; SSF54631; SSF54631; 1.
DR TIGRFAMs; TIGR00400; mgtE; 1.
DR PROSITE; PS51371; CBS; 2.
PE 3: Inferred from homology;
KW CBS domain; Cell membrane; Magnesium; Membrane; Metal-binding;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..451
FT /note="Magnesium transporter MgtE"
FT /id="PRO_0000363887"
FT TOPO_DOM 1..277
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 278..305
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250"
FT INTRAMEM 306..320
FT /evidence="ECO:0000250"
FT TRANSMEM 321..344
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250"
FT TOPO_DOM 345..351
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 352..382
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250"
FT INTRAMEM 383..386
FT /evidence="ECO:0000250"
FT TRANSMEM 387..415
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250"
FT INTRAMEM 416..425
FT /evidence="ECO:0000250"
FT TRANSMEM 426..448
FT /note="Helical; Name=5"
FT /evidence="ECO:0000250"
FT TOPO_DOM 449..451
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT DOMAIN 140..203
FT /note="CBS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT DOMAIN 204..260
FT /note="CBS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703"
FT BINDING 96
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 216
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
FT BINDING 218
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="4"
FT /evidence="ECO:0000250"
FT BINDING 228
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="5"
FT /evidence="ECO:0000250"
FT BINDING 249
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 257
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
FT BINDING 260
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
FT BINDING 261
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="4"
FT /evidence="ECO:0000250"
FT BINDING 419
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="4"
FT /evidence="ECO:0000250"
FT BINDING 433
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="6"
FT /evidence="ECO:0000250"
SQ SEQUENCE 451 AA; 50844 MW; 5103B96F03EA09C0 CRC64;
MVQNMTYDEL ILRIIILLRD GKIRDFRSVI DELQPYDMAF IFKEMPEKHR ARYLSYLTVD
DITDMIGELE REFQLVVLNK VGKTKATLAM NKMDNDDLAQ LLEEMDEELK EQLLSSMEAS
ESKAVQLLMN YPADSAGRMM TNRYVWIPQH YTVKDAVVKL KSFAEIAESI NYLYVINESK
QLVGVLSYRD LILGEPEEKV QDLMFTRVIS ADALQDQEEV ARLIERYDFL AIPVVEENNV
LVGIVTVDDI IDVVIREADE DYEKFAASGK DITFDTKAYV AAYRRLPWLI LLLFIGLISG
SIISYFEDAL KQVVALAFFM PMVSGMTGNT GTQSLAVVIR GLSKEEMNKK TIVRLIFREF
RTSIFIGAVC SVLIAIVSII WQGNALLGFV VASSLFLTLI IGTMSGTIIP IILHKLKVDP
AIASGPLITT LNDILSLLIY FGIATAFIHS L
