ID   MGT_STRLI               Reviewed;         418 AA.
AC   Q54387;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Macrolide glycosyltransferase;
DE            EC=2.4.1.-;
GN   Name=mgt; Synonyms=UGT102A1;
OS   Streptomyces lividans.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1916;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1761231; DOI=10.1016/0378-1119(91)90487-v;
RA   Jenkins G., Cundliffe E.;
RT   "Cloning and characterization of two genes from Streptomyces lividans that
RT   confer inducible resistance to lincomycin and macrolide antibiotics.";
RL   Gene 108:55-62(1991).
CC   -!- FUNCTION: Specifically inactivates macrolides via 2'-O-glycosylation
CC       using UDP-glucose.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; M74717; AAA26780.1; -; Genomic_DNA.
DR   PIR; JS0636; JS0636.
DR   RefSeq; WP_063853740.1; NG_047982.1.
DR   AlphaFoldDB; Q54387; -.
DR   SMR; Q54387; -.
DR   CAZy; GT1; Glycosyltransferase Family 1.
DR   GO; GO:0016758; F:hexosyltransferase activity; IEA:InterPro.
DR   GO; GO:0008194; F:UDP-glycosyltransferase activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd03784; GT1_Gtf-like; 1.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   InterPro; IPR006326; UDPGT_MGT-like.
DR   Pfam; PF00201; UDPGT; 1.
DR   TIGRFAMs; TIGR01426; MGT; 1.
DR   PROSITE; PS00375; UDPGT; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Glycosyltransferase; Transferase.
FT   CHAIN           1..418
FT                   /note="Macrolide glycosyltransferase"
FT                   /id="PRO_0000074164"
SQ   SEQUENCE   418 AA;  45683 MW;  F7349765ECE8D2E4 CRC64;
     MKRKELHETS RLAYGRRMTT RPAHIAMFSI ALHGHVNPSL EVIRELVARG HRVTYAIPRL
     LADKVAEAGA EPKLWNSTLP GPDADPEAWG STLLDNVEPF LADAIQSLPQ LAQAYEGDEP
     DLVLHDIASY TARVLGRRWE VPVISLSPCM VAWEGYEQEV GEPMWEEPRK TERGQAYYAR
     FHAWLEENGI TDHPDPFIGR PDRSLVLIPK ALQPHADRVD ETTYTFVGAC QGDRTAEGDW
     ARPEGAEKVV LVSLGSAFTK QPAFYRECVR AFGELPGWHT VLQVGRHVDP AELGDVPDNV
     EVRTWVPQLA ILQQADLFVT HAGAGGSQEG LATATPMIAV PQAADQFGNA DMLQGLGVAR
     TLPTEEATAK ALRTAALALV DDPEVAARLK EIQARMAQEA GTRGPADLIE AELAAARG