位置:首页 > 蛋白库 > MHPD_PARP8
MHPD_PARP8
ID   MHPD_PARP8              Reviewed;         262 AA.
AC   B2JQV8;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=2-keto-4-pentenoate hydratase {ECO:0000255|HAMAP-Rule:MF_01655};
DE            EC=4.2.1.80 {ECO:0000255|HAMAP-Rule:MF_01655};
DE   AltName: Full=2-hydroxypentadienoic acid hydratase {ECO:0000255|HAMAP-Rule:MF_01655};
GN   Name=mhpD {ECO:0000255|HAMAP-Rule:MF_01655}; OrderedLocusNames=Bphy_4537;
OS   Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 /
OS   STM815) (Burkholderia phymatum).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=391038;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17167 / CIP 108236 / LMG 21445 / STM815;
RX   PubMed=25197461; DOI=10.4056/sigs.4861021;
RA   Moulin L., Klonowska A., Caroline B., Booth K., Vriezen J.A., Melkonian R.,
RA   James E.K., Young J.P., Bena G., Hauser L., Land M., Kyrpides N., Bruce D.,
RA   Chain P., Copeland A., Pitluck S., Woyke T., Lizotte-Waniewski M.,
RA   Bristow J., Riley M.;
RT   "Complete genome sequence of Burkholderia phymatum STM815(T), a broad host
RT   range and efficient nitrogen-fixing symbiont of Mimosa species.";
RL   Stand. Genomic Sci. 9:763-774(2014).
CC   -!- FUNCTION: Catalyzes the conversion of 2-hydroxypentadienoic acid
CC       (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid.
CC       {ECO:0000255|HAMAP-Rule:MF_01655}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-4-hydroxy-2-oxopentanoate = (2Z)-2-hydroxypenta-2,4-
CC         dienoate + H2O; Xref=Rhea:RHEA:22580, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:67152, ChEBI:CHEBI:73143; EC=4.2.1.80;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01655};
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01655};
CC   -!- PATHWAY: Aromatic compound metabolism; 3-phenylpropanoate degradation.
CC       {ECO:0000255|HAMAP-Rule:MF_01655}.
CC   -!- SIMILARITY: Belongs to the hydratase/decarboxylase family. MhpD
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01655}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP001044; ACC73649.1; -; Genomic_DNA.
DR   RefSeq; WP_012403821.1; NZ_CADFGH010000009.1.
DR   AlphaFoldDB; B2JQV8; -.
DR   SMR; B2JQV8; -.
DR   STRING; 391038.Bphy_4537; -.
DR   EnsemblBacteria; ACC73649; ACC73649; Bphy_4537.
DR   KEGG; bph:Bphy_4537; -.
DR   eggNOG; COG3971; Bacteria.
DR   HOGENOM; CLU_060136_4_1_4; -.
DR   OMA; IRDWSIG; -.
DR   OrthoDB; 1314120at2; -.
DR   UniPathway; UPA00714; -.
DR   Proteomes; UP000001192; Chromosome 2.
DR   GO; GO:0008684; F:2-oxopent-4-enoate hydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR   GO; GO:0019380; P:3-phenylpropionate catabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.90.850.10; -; 1.
DR   HAMAP; MF_01655; MhpD; 1.
DR   InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR   InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR   InterPro; IPR023793; Keto_pentenoate-hydratase.
DR   Pfam; PF01557; FAA_hydrolase; 1.
DR   SUPFAM; SSF56529; SSF56529; 1.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; Lyase; Reference proteome.
FT   CHAIN           1..262
FT                   /note="2-keto-4-pentenoate hydratase"
FT                   /id="PRO_1000187019"
SQ   SEQUENCE   262 AA;  27747 MW;  08DE8963582ED739 CRC64;
     MSDDNRIESM AARLREAQSS RQTIAPLREA CPEGDATLAY AIQQVNNDLR AANGERLVGR
     KIGLTSPAVQ KQLGVGQPDF GALFASMAYG DSQPMPLASL VQPKVEAEIA LVLERDLTAE
     KNTFADLIGA TAYALAAIEV VDSRIRDWDI RFFDTVADNA SSALFVLGSR PVLLRDIDLT
     ACAMTLTQDG EILSRGNGTA CLGNPLNAAA WLADRMVRLG TPLRAGDIVL TGALGPMVAV
     KAAGTYTAHI EGLGSVRASF SE
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024