MHPR_ECOLI
ID MHPR_ECOLI Reviewed; 277 AA.
AC P77569; P71202; Q2MC78;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2007, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=DNA-binding transcriptional activator MhpR {ECO:0000305};
DE AltName: Full=mhp operon transcriptional activator;
GN Name=mhpR; OrderedLocusNames=b0346, JW0337;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=K12 / CS520;
RX PubMed=9098055; DOI=10.1128/jb.179.8.2573-2581.1997;
RA Ferrandez A., Garcia J.L., Diaz E.;
RT "Genetic characterization and expression in heterologous hosts of the 3-(3-
RT hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12.";
RL J. Bacteriol. 179:2573-2581(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RA Kawamukai M.;
RT "Complete sequence of the mhp operon.";
RL Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RA Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT "Sequence of minutes 4-25 of Escherichia coli.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
CC -!- FUNCTION: Activator of the mhpABCDFE operon coding for components of
CC the 3-hydroxyphenylpropionate degradation pathway.
CC {ECO:0000269|PubMed:9098055}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB18070.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAA13051.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE76128.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAA70746.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; Y09555; CAA70746.1; ALT_INIT; Genomic_DNA.
DR EMBL; D86239; BAA13051.1; ALT_INIT; Genomic_DNA.
DR EMBL; U73857; AAB18070.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC73449.2; -; Genomic_DNA.
DR EMBL; AP009048; BAE76128.1; ALT_INIT; Genomic_DNA.
DR PIR; B64762; B64762.
DR RefSeq; NP_414880.2; NC_000913.3.
DR RefSeq; WP_001301325.1; NZ_SSZK01000061.1.
DR AlphaFoldDB; P77569; -.
DR SMR; P77569; -.
DR BioGRID; 4260667; 12.
DR DIP; DIP-10211N; -.
DR IntAct; P77569; 4.
DR STRING; 511145.b0346; -.
DR jPOST; P77569; -.
DR PaxDb; P77569; -.
DR PRIDE; P77569; -.
DR DNASU; 945938; -.
DR EnsemblBacteria; AAC73449; AAC73449; b0346.
DR EnsemblBacteria; BAE76128; BAE76128; BAE76128.
DR GeneID; 945938; -.
DR KEGG; ecj:JW0337; -.
DR KEGG; eco:b0346; -.
DR PATRIC; fig|1411691.4.peg.1932; -.
DR EchoBASE; EB4169; -.
DR eggNOG; COG1414; Bacteria.
DR HOGENOM; CLU_062618_1_0_6; -.
DR InParanoid; P77569; -.
DR PhylomeDB; P77569; -.
DR BioCyc; EcoCyc:G6201-MON; -.
DR PRO; PR:P77569; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF09339; HTH_IclR; 1.
DR Pfam; PF01614; IclR; 1.
DR SMART; SM00346; HTH_ICLR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS51077; HTH_ICLR; 1.
DR PROSITE; PS51078; ICLR_ED; 1.
PE 4: Predicted;
KW Activator; Aromatic hydrocarbons catabolism; DNA-binding;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..277
FT /note="DNA-binding transcriptional activator MhpR"
FT /id="PRO_0000201763"
FT DOMAIN 12..74
FT /note="HTH iclR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT DOMAIN 89..262
FT /note="IclR-ED"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00394"
FT DNA_BIND 34..53
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT CONFLICT 249
FT /note="L -> Q (in Ref. 2; BAA13051)"
FT /evidence="ECO:0000305"
FT CONFLICT 256..277
FT /note="IEEGVESQAILVAGRRSGMHLR -> NRRRG (in Ref. 2;
FT BAA13051)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 277 AA; 31322 MW; 79240A3D14165AAB CRC64;
MQNNEQTEYK TVRGLTRGLM LLNMLNKLDG GASVGLLAEL SGLHRTTVRR LLETLQEEGY
VRRSPSDDSF RLTIKVRQLS EGFRDEQWIS ALAAPLLGDL LREVVWPTDV STLDVDAMVV
RETTHRFSRL SFHRAMVGRR LPLLKTASGL TWLAFCPEQD RKELIEMLAS RPGDDYQLAR
EPLKLEAILA RARKEGYGQN YRGWDQEEKI ASIAVPLRSE QRVIGCLNLV YMASAMTIEQ
AAEKHLPALQ RVAKQIEEGV ESQAILVAGR RSGMHLR
