MHR1_KLULA
ID MHR1_KLULA Reviewed; 219 AA.
AC Q6CTS4;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Mitochondrial homologous recombination protein 1;
GN Name=MHR1; OrderedLocusNames=KLLA0C10439g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Transcription factor involved in regulation of RNA polymerase
CC II-dependent transcription. Also involved in regulation of
CC mitochondrial DNA recombination, maintenance and repair, and generation
CC of homoplasmic cells (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Mitochondrion
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC mL67 family. {ECO:0000305}.
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DR EMBL; CR382123; CAH01516.1; -; Genomic_DNA.
DR RefSeq; XP_452665.1; XM_452665.1.
DR AlphaFoldDB; Q6CTS4; -.
DR SMR; Q6CTS4; -.
DR STRING; 28985.XP_452665.1; -.
DR EnsemblFungi; CAH01516; CAH01516; KLLA0_C10439g.
DR GeneID; 2891994; -.
DR KEGG; kla:KLLA0_C10439g; -.
DR eggNOG; ENOG502QSKX; Eukaryota.
DR HOGENOM; CLU_092898_0_0_1; -.
DR InParanoid; Q6CTS4; -.
DR OMA; WENRKPS; -.
DR Proteomes; UP000000598; Chromosome C.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; IEA:EnsemblFungi.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000150; F:DNA strand exchange activity; IEA:EnsemblFungi.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:EnsemblFungi.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:EnsemblFungi.
DR GO; GO:0034599; P:cellular response to oxidative stress; IEA:EnsemblFungi.
DR GO; GO:0000002; P:mitochondrial genome maintenance; IEA:EnsemblFungi.
DR GO; GO:0090297; P:positive regulation of mitochondrial DNA replication; IEA:EnsemblFungi.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:EnsemblFungi.
DR InterPro; IPR024629; Mhr1.
DR PANTHER; PTHR28184; PTHR28184; 1.
DR Pfam; PF12829; Mhr1; 1.
PE 3: Inferred from homology;
KW Mitochondrion; Nucleus; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; Transcription; Transcription regulation.
FT CHAIN 1..219
FT /note="Mitochondrial homologous recombination protein 1"
FT /id="PRO_0000255965"
SQ SEQUENCE 219 AA; 26027 MW; 39FF3C037580E169 CRC64;
MSKHLAITKF RPANWLQKAG YAPQVFLFRN LESGQVLYSQ FPTFSWKQID TNFQRPNWEN
KKPSTRRDIW KCMAVVDLPD YDKSVKVYQN LCRLRYLRDV TFSKQAKDMR KKNESGHTWY
SSQYRPTYSQ EAVADLRECL LKLKDVQSSI KVHWEDEWRM GDKEKYWNPV LPELNHTTLE
RLGNVSREES AILKELGERA KEEFARVRQQ ESAAQNISL