MHX1_ORYSJ
ID MHX1_ORYSJ Reviewed; 523 AA.
AC Q2R041; A0A0P0Y543; B9G8Q2; Q2R040;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Magnesium/proton exchanger 1;
DE AltName: Full=Mg(2+)/H(+) exchanger 1;
DE AltName: Full=Zinc/proton exchanger 1;
DE AltName: Full=Zn(2+)/H(+) exchanger 1;
GN Name=MHX1; OrderedLocusNames=Os11g0660000, LOC_Os11g43860;
GN ORFNames=OsJ_34726;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG The rice chromosomes 11 and 12 sequencing consortia;
RT "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT genes and recent gene duplications.";
RL BMC Biol. 3:20-20(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
CC -!- FUNCTION: Vacuolar transporter that exchanges protons with Mg(2+),
CC Zn(2+) and Fe(2+) ions. May control the partitioning of Mg(2+) and
CC Zn(2+) between plant organs (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q2R041-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q2R041-2; Sequence=VSP_042813, VSP_042814;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to an intron retention.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. MHX subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EEE52517.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; DP000010; ABA95194.1; -; Genomic_DNA.
DR EMBL; DP000010; ABA95195.1; -; Genomic_DNA.
DR EMBL; AP008217; BAF28765.1; -; Genomic_DNA.
DR EMBL; AP014967; BAT15131.1; -; Genomic_DNA.
DR EMBL; CM000148; EEE52517.1; ALT_INIT; Genomic_DNA.
DR EMBL; AK066709; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015618036.1; XM_015762550.1. [Q2R041-1]
DR AlphaFoldDB; Q2R041; -.
DR STRING; 4530.OS11T0660000-01; -.
DR PaxDb; Q2R041; -.
DR PRIDE; Q2R041; -.
DR EnsemblPlants; Os11t0660000-01; Os11t0660000-01; Os11g0660000. [Q2R041-1]
DR GeneID; 4351058; -.
DR Gramene; Os11t0660000-01; Os11t0660000-01; Os11g0660000. [Q2R041-1]
DR KEGG; osa:4351058; -.
DR eggNOG; KOG1306; Eukaryota.
DR HOGENOM; CLU_012872_2_0_1; -.
DR InParanoid; Q2R041; -.
DR OMA; RLWAWIT; -.
DR OrthoDB; 490546at2759; -.
DR Proteomes; UP000000763; Chromosome 11.
DR Proteomes; UP000007752; Chromosome 11.
DR Proteomes; UP000059680; Chromosome 11.
DR Genevisible; Q2R041; OS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015491; F:cation:cation antiporter activity; IBA:GO_Central.
DR GO; GO:0030001; P:metal ion transport; IBA:GO_Central.
DR Gene3D; 1.20.1420.30; -; 2.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Vacuole.
FT CHAIN 1..523
FT /note="Magnesium/proton exchanger 1"
FT /id="PRO_0000416778"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 461..481
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 495..515
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 425..434
FT /note="SNSVNIYVGI -> RYISAHLLSN (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_042813"
FT VAR_SEQ 435..523
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_042814"
FT CONFLICT 232
FT /note="E -> K (in Ref. 6; AK066709)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 523 AA; 58160 MW; A1032E24B214B427 CRC64;
MANINMADTV PSCDTYLLFN GETLLPIGVR AFIYTAVLAY CFIGLSAITG RFFKSMESIM
RHSREVVTVD PHTNATIVKH EKVWNYTIAD VALLAFGTSF PQISLATIDA IRNLGQLTAG
GLGPGTLVGS AAFDLFPIHA VCVVMPRAGS KKKISDLGVW LVELFWSFWA YIWLYIILEV
WTPRVITLWE ALLTVLQYGL LLLHAYAQDK RWPYVSIPLA RGERPEDWVP AEDASVDYDD
NYDGIGDILP GQNEDIVDIF SAHSYSNEGY HHVSEEDVEE SSTGLTLKNK WEDTHWFSIW
WQQFVDAATL ESSVSRKMDS TCLRVIGISW NLIIAPWKML FAFVPPYEIA HGWIAFICSL
IFISGIAYGV TKITDQISCV TGVSPYVIAF TALAAGTSWP DLVASKIAAE RQITADSAIT
NITCSNSVNI YVGIGVPWLV DTMYNYFVYQ KPLYIDNAAG LSFSLLVFFA TSFGCITVLV
LRRVILGAEL GGPRMWAWAT SVYFMILWVV FVVLSSLKIS GVI
