ID   MHX2_ORYSJ              Reviewed;         524 AA.
AC   Q6H641; Q0DZ55;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2012, sequence version 2.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Magnesium/proton exchanger 2;
DE   AltName: Full=Mg(2+)/H(+) exchanger 2;
DE   AltName: Full=Zinc/proton exchanger 2;
DE   AltName: Full=Zn(2+)/H(+) exchanger 2;
GN   Name=MHX2; OrderedLocusNames=Os02g0644900, LOC_Os02g43110;
GN   ORFNames=OJ1282_H11.33, P0030D07.11;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
CC   -!- FUNCTION: Vacuolar transporter that exchanges protons with Mg(2+),
CC       Zn(2+) and Fe(2+) ions. May control the partitioning of Mg(2+) and
CC       Zn(2+) between plant organs (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC       family. MHX subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAD25799.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BAD25808.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BAF09483.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AP005291; BAD25799.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP005306; BAD25808.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP008208; BAF09483.2; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP014958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q6H641; -.
DR   STRING; 39947.Q6H641; -.
DR   PRIDE; Q6H641; -.
DR   InParanoid; Q6H641; -.
DR   Proteomes; UP000000763; Chromosome 2.
DR   Proteomes; UP000059680; Chromosome 2.
DR   Genevisible; Q6H641; OS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015491; F:cation:cation antiporter activity; IBA:GO_Central.
DR   GO; GO:0030001; P:metal ion transport; IBA:GO_Central.
DR   Gene3D; 1.20.1420.30; -; 2.
DR   InterPro; IPR004837; NaCa_Exmemb.
DR   InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR   Pfam; PF01699; Na_Ca_ex; 2.
PE   3: Inferred from homology;
KW   Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport; Vacuole.
FT   CHAIN           1..524
FT                   /note="Magnesium/proton exchanger 2"
FT                   /id="PRO_0000416779"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        325..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        349..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        430..450
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        462..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        496..516
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   524 AA;  58261 MW;  EB22AB35230A9ECC CRC64;
     MANINMADTA PSCDTYLLFN GETLLPNGVR AFIYTVVLAY CFIGLSAISG RFFKSMESIM
     RHSREVVTID PHTNATIVKH EKVWNYTIAD VALLAFGTSF PQISLATIDA IRNLGQLTAG
     GLGPGTLVGS AAFDLFPIHA VCVVMPRAGS KKKISDLGVW LVELFWSFWA YIWLYIILEV
     WTPRVITLWE ALLTVLQYGL LLLHAYAQDK RWPYVSIPLA RGDRPEDWVP TEDASVDYDD
     NYDGIGDILP GQNEDIVDIF SARSYSNEGY HHVSEKDVEE SPTGLTLKNK WEDTHWFSIW
     WQQFVDAATL ESSVSRKMDS TCLSVIGISW NLIIAPWKML FAFIPPYEIA HGWIAFICSL
     IFISGIAYGV TKITDQISCV TGVSPYVIAF TALAAGTSWP DLVASKIAAE RQITADSAIA
     NITCSNSVNI YVGIGVPWLV DTMYNYLFVY KKPLYIDNAA GLSFSLLVFF ATSFGCITVL
     VLRRVILGAE LGGPRMWAWA TSVYFMILWV VFVVLSSLRI SGVI