ID   MHX_ARAHH               Reviewed;         539 AA.
AC   B8K1V7;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 20.
DE   RecName: Full=Magnesium/proton exchanger;
DE   AltName: Full=Mg(2+)/H(+) exchanger;
DE            Short=AhMHX;
DE   AltName: Full=Zinc/proton exchanger;
DE   AltName: Full=Zn(2+)/H(+) exchanger;
GN   Name=MHX;
OS   Arabidopsis halleri subsp. halleri (Arabis halleri).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=81971;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND
RP   FUNCTION.
RX   PubMed=17080942; DOI=10.1111/j.1365-3040.2006.01500.x;
RA   Elbaz B., Shoshani-Knaani N., David-Assael O., Mizrachy-Dagri T.,
RA   Mizrahi K., Saul H., Brook E., Berezin I., Shaul O.;
RT   "High expression in leaves of the zinc hyperaccumulator Arabidopsis halleri
RT   of AhMHX, a homolog of an Arabidopsis thaliana vacuolar metal/proton
RT   exchanger.";
RL   Plant Cell Environ. 29:1179-1190(2006).
CC   -!- FUNCTION: Vacuolar transporter that exchanges protons with Mg(2+),
CC       Zn(2+) and Fe(2+) ions. May control the partitioning of Mg(2+) and
CC       Zn(2+) between plant organs. Could play a role in Zn(2+) accumulation
CC       or tolerance. {ECO:0000269|PubMed:17080942}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: High expression in leaves (at protein level).
CC       {ECO:0000269|PubMed:17080942}.
CC   -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC       family. MHX subfamily. {ECO:0000305}.
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DR   EMBL; DQ118861; AAZ68034.1; -; mRNA.
DR   AlphaFoldDB; B8K1V7; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1420.30; -; 2.
DR   InterPro; IPR004837; NaCa_Exmemb.
DR   InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR   Pfam; PF01699; Na_Ca_ex; 2.
PE   1: Evidence at protein level;
KW   Ion transport; Membrane; Transmembrane; Transmembrane helix; Transport;
KW   Vacuole.
FT   CHAIN           1..539
FT                   /note="Magnesium/proton exchanger"
FT                   /id="PRO_0000416776"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        392..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        444..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        477..497
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        511..531
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   539 AA;  59749 MW;  3F08C0B2368FBB92 CRC64;
     MASILNQTQE LQEASKVLGH VRCENFFIFP GENTLSDGLR GVLYFLGLAY CFIGLSAITA
     RFFKSMENVV KHSRKVVAID PITKAEIITY KKVWNFTIAD ISLLAFGTSF PQISLATIDA
     IRNIGERYAG GLGPGTLVGS AAFDLFPIHA VCVVVPKAGE LKKISDLGVW LVELVWSFWA
     YIWLYIILEV WSPNVITLVE ALLTVLQYGL LLVHAYAQDK RWPYLSLPMS RGDRPEEWVP
     EEIDTSKDDN DNDVHDVYSD AAQEAVESGS RNIVDIFSIH SANNDTGITY HTVADTPPDS
     ATKKGKAKNS SVFDIWKHQF VDAITLETSE SKKVDSIYLR IANSFWQLLL APWKLLFAFV
     PPCNIAHGWI AFIFSLLFIS GVAFVVTRFT DLISCVTGIN PYVIAFTALA SGTSWPDLVA
     SKIAAERQLT ADSAIANITC SNSVNIYVGI GVPWLINTVY NYFAYREPLY IENAKGLSFS
     LLIFFATSVG CIVVLVLRRL IIGAELGGPR LWAWLTSAYF MMLWVVFVVL SSLKVSGVI