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MHX_ARATH
ID   MHX_ARATH               Reviewed;         539 AA.
AC   O22252; Q9S7N1;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 3.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Magnesium/proton exchanger;
DE   AltName: Full=Mg(2+)/H(+) exchanger;
DE            Short=AtMHX;
DE   AltName: Full=Zinc/proton exchanger;
DE   AltName: Full=Zn(2+)/H(+) exchanger;
GN   Name=MHX; Synonyms=MHX1; OrderedLocusNames=At2g47600; ORFNames=T30B22.10;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, SUBCELLULAR LOCATION,
RP   AND TISSUE SPECIFICITY.
RC   STRAIN=cv. C24;
RX   PubMed=10406802; DOI=10.1093/emboj/18.14.3973;
RA   Shaul O., Hilgemann D.W., de-Almeida-Engler J., Van Montagu M., Inz D.,
RA   Galili G.;
RT   "Cloning and characterization of a novel Mg(2+)/H(+) exchanger.";
RL   EMBO J. 18:3973-3980(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   FUNCTION.
RX   PubMed=12206396; DOI=10.1023/a:1016091118585;
RA   Shaul O.;
RT   "Magnesium transport and function in plants: the tip of the iceberg.";
RL   BioMetals 15:309-323(2002).
RN   [6]
RP   FUNCTION.
RX   PubMed=17080942; DOI=10.1111/j.1365-3040.2006.01500.x;
RA   Elbaz B., Shoshani-Knaani N., David-Assael O., Mizrachy-Dagri T.,
RA   Mizrahi K., Saul H., Brook E., Berezin I., Shaul O.;
RT   "High expression in leaves of the zinc hyperaccumulator Arabidopsis halleri
RT   of AhMHX, a homolog of an Arabidopsis thaliana vacuolar metal/proton
RT   exchanger.";
RL   Plant Cell Environ. 29:1179-1190(2006).
RN   [7]
RP   FUNCTION.
RX   PubMed=18327593; DOI=10.1007/s00299-007-0502-9;
RA   Berezin I., Mizrachy-Dagry T., Brook E., Mizrahi K., Elazar M., Zhuo S.,
RA   Saul-Tcherkas V., Shaul O.;
RT   "Overexpression of AtMHX in tobacco causes increased sensitivity to Mg2+,
RT   Zn2+, and Cd2+ ions, induction of V-ATPase expression, and a reduction in
RT   plant size.";
RL   Plant Cell Rep. 27:939-949(2008).
CC   -!- FUNCTION: Vacuolar transporter that exchanges protons with Mg(2+),
CC       Zn(2+) and Fe(2+) ions. May control the partitioning of Mg(2+) and
CC       Zn(2+) between plant organs. Could also transport Cd(2+) in vitro.
CC       {ECO:0000269|PubMed:10406802, ECO:0000269|PubMed:12206396,
CC       ECO:0000269|PubMed:17080942, ECO:0000269|PubMed:18327593}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000269|PubMed:10406802};
CC       Multi-pass membrane protein {ECO:0000269|PubMed:10406802}.
CC   -!- TISSUE SPECIFICITY: Mainly expressed in the vascular cylinder.
CC       {ECO:0000269|PubMed:10406802}.
CC   -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC       family. MHX subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AY080737; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AF109178; AAF14229.1; -; mRNA.
DR   EMBL; AF109182; AAF14230.1; -; Genomic_DNA.
DR   EMBL; AC002535; AAC62871.2; -; Genomic_DNA.
DR   EMBL; CP002685; AEC10863.1; -; Genomic_DNA.
DR   EMBL; AY080737; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; T00424; T00424.
DR   RefSeq; NP_566105.1; NM_130328.3.
DR   AlphaFoldDB; O22252; -.
DR   BioGRID; 4708; 30.
DR   IntAct; O22252; 25.
DR   STRING; 3702.AT2G47600.1; -.
DR   TCDB; 2.A.19.6.1; the ca(2+):cation antiporter (caca) family.
DR   PaxDb; O22252; -.
DR   PRIDE; O22252; -.
DR   ProteomicsDB; 250848; -.
DR   EnsemblPlants; AT2G47600.1; AT2G47600.1; AT2G47600.
DR   GeneID; 819373; -.
DR   Gramene; AT2G47600.1; AT2G47600.1; AT2G47600.
DR   KEGG; ath:AT2G47600; -.
DR   Araport; AT2G47600; -.
DR   TAIR; locus:2061951; AT2G47600.
DR   eggNOG; KOG1306; Eukaryota.
DR   HOGENOM; CLU_012872_2_0_1; -.
DR   InParanoid; O22252; -.
DR   OMA; RLWAWIT; -.
DR   OrthoDB; 490546at2759; -.
DR   PhylomeDB; O22252; -.
DR   PRO; PR:O22252; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; O22252; baseline and differential.
DR   Genevisible; O22252; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015491; F:cation:cation antiporter activity; IBA:GO_Central.
DR   GO; GO:0030001; P:metal ion transport; IBA:GO_Central.
DR   Gene3D; 1.20.1420.30; -; 2.
DR   InterPro; IPR004837; NaCa_Exmemb.
DR   InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR   Pfam; PF01699; Na_Ca_ex; 2.
PE   2: Evidence at transcript level;
KW   Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport; Vacuole.
FT   CHAIN           1..539
FT                   /note="Magnesium/proton exchanger"
FT                   /id="PRO_0000416777"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        392..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        444..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        477..497
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        511..531
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   539 AA;  59792 MW;  71036ACE8AD920A9 CRC64;
     MASILNQTQE LQESSKVLGH LRCENFFLFP GENTLSDGLR GVLYFLGLAY CFIGLSAITA
     RFFKSMENVV KHSRKVVTID PITKAEVITY KKVWNFTIAD ISLLAFGTSF PQISLATIDA
     IRNMGERYAG GLGPGTLVGS AAFDLFPIHA VCVVVPKAGE LKKISDLGVW LVELVWSFWA
     YIWLYIILEV WSPNVITLVE ALLTVLQYGL LLVHAYAQDK RWPYLSLPMS RGDRPEEWVP
     EEIDTSKDDN DNDVHDVYSD AAQDAVESGS RNIVDIFSIH SANNDTGITY HTVADTPPDS
     ATKKGKAKNS TVFDIWKHQF VDAITLETSE SKKVDSIYLR IAKSFWHLLL APWKLLFAFV
     PPCNIAHGWI AFICSLLFIS GVAFVVTRFT DLISCVTGIN PYVIAFTALA SGTSWPDLVA
     SKIAAERQLT ADSAIANITC SNSVNIYVGI GVPWLINTVY NYFAYREPLY IENAKGLSFS
     LLIFFATSVG CIVVLVLRRL IIGAELGGPR LWAWLTSAYF MMLWVVFVVL SSLKVSGVI
 
 
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