ID   MI4GD_BOVIN             Reviewed;         222 AA.
AC   Q3ZC21;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=MIF4G domain-containing protein;
GN   Name=MIF4GD;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions in replication-dependent translation of histone
CC       mRNAs which differ from other eukaryotic mRNAs in that they do not end
CC       with a poly-A tail but a stem-loop. May participate in circularizing
CC       those mRNAs specifically enhancing their translation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with EIF4G1, EIF4G2 and SLBP; probably tethered by
CC       SLBP to the 3'-end of mRNAs ending with the histone stem-loop, it also
CC       interacts with EIF4G1 which is bound to their 5'-end. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MIF4GD family. {ECO:0000305}.
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DR   EMBL; BC102971; AAI02972.1; -; mRNA.
DR   RefSeq; NP_001029904.1; NM_001034732.1.
DR   AlphaFoldDB; Q3ZC21; -.
DR   SMR; Q3ZC21; -.
DR   STRING; 9913.ENSBTAP00000034575; -.
DR   PaxDb; Q3ZC21; -.
DR   Ensembl; ENSBTAT00000034689; ENSBTAP00000034575; ENSBTAG00000030168.
DR   GeneID; 613305; -.
DR   KEGG; bta:613305; -.
DR   CTD; 57409; -.
DR   VEuPathDB; HostDB:ENSBTAG00000030168; -.
DR   VGNC; VGNC:31472; MIF4GD.
DR   eggNOG; KOG3942; Eukaryota.
DR   GeneTree; ENSGT00940000153432; -.
DR   HOGENOM; CLU_081010_1_0_1; -.
DR   InParanoid; Q3ZC21; -.
DR   OMA; KVNSQRM; -.
DR   OrthoDB; 1168859at2759; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000030168; Expressed in corpus luteum and 105 other tissues.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0062073; C:histone mRNA stem-loop binding complex; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008494; F:translation activator activity; IBA:GO_Central.
DR   GO; GO:0002191; P:cap-dependent translational initiation; IEA:Ensembl.
DR   GO; GO:0006446; P:regulation of translational initiation; IBA:GO_Central.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   Pfam; PF02854; MIF4G; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Translation regulation.
FT   CHAIN           1..222
FT                   /note="MIF4G domain-containing protein"
FT                   /id="PRO_0000337088"
FT   DOMAIN          3..205
FT                   /note="MIF4G"
SQ   SEQUENCE   222 AA;  25395 MW;  00E1888ABC1422AE CRC64;
     MGEPSKEEYK IQCFDAETQQ LLKTALKDPG AVDLEKVANV IVDHSLQDSV FSKEAGRMCY
     AIIQAESKQA GQSVFRRGLL NRLQQEYQTR EQLRARSLQG WVCYVTFICN IFDYLRVNNM
     PMMALVNPVY DCLFRLAQPD SLSKEEEVDC LVLQLHRVGE QLEKMNGQRM DELFVLIRDG
     FLLPAGLSSL AQLLLLEIIE FRAAGWKTTP AAHKYYYSEV SD