ID   MI4GD_RAT               Reviewed;         222 AA.
AC   Q6AXU7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=MIF4G domain-containing protein;
GN   Name=Mif4gd;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Functions in replication-dependent translation of histone
CC       mRNAs which differ from other eukaryotic mRNAs in that they do not end
CC       with a poly-A tail but a stem-loop. May participate in circularizing
CC       those mRNAs specifically enhancing their translation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with EIF4G1, EIF4G2 and SLBP; probably tethered by
CC       SLBP to the 3'-end of mRNAs ending with the histone stem-loop, it also
CC       interacts with EIF4G1 which is bound to their 5'-end. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MIF4GD family. {ECO:0000305}.
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DR   EMBL; BC079310; AAH79310.1; -; mRNA.
DR   RefSeq; NP_001014144.1; NM_001014122.1.
DR   RefSeq; XP_006247784.1; XM_006247722.1.
DR   AlphaFoldDB; Q6AXU7; -.
DR   SMR; Q6AXU7; -.
DR   IntAct; Q6AXU7; 1.
DR   STRING; 10116.ENSRNOP00000005198; -.
DR   jPOST; Q6AXU7; -.
DR   PaxDb; Q6AXU7; -.
DR   PRIDE; Q6AXU7; -.
DR   DNASU; 360659; -.
DR   GeneID; 360659; -.
DR   KEGG; rno:360659; -.
DR   CTD; 57409; -.
DR   RGD; 1309685; Mif4gd.
DR   VEuPathDB; HostDB:ENSRNOG00000003918; -.
DR   eggNOG; KOG3942; Eukaryota.
DR   HOGENOM; CLU_081010_1_0_1; -.
DR   InParanoid; Q6AXU7; -.
DR   OMA; KVNSQRM; -.
DR   OrthoDB; 1168859at2759; -.
DR   PhylomeDB; Q6AXU7; -.
DR   PRO; PR:Q6AXU7; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000003837; Expressed in testis and 20 other tissues.
DR   Genevisible; Q6AXU7; RN.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0062073; C:histone mRNA stem-loop binding complex; ISO:RGD.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0008022; F:protein C-terminus binding; ISO:RGD.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008494; F:translation activator activity; IBA:GO_Central.
DR   GO; GO:0002191; P:cap-dependent translational initiation; ISO:RGD.
DR   GO; GO:0006446; P:regulation of translational initiation; IBA:GO_Central.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   Pfam; PF02854; MIF4G; 1.
DR   SMART; SM00543; MIF4G; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Translation regulation.
FT   CHAIN           1..222
FT                   /note="MIF4G domain-containing protein"
FT                   /id="PRO_0000337091"
FT   DOMAIN          3..205
FT                   /note="MIF4G"
SQ   SEQUENCE   222 AA;  25471 MW;  95872F70700B931F CRC64;
     MGEASRDEYK IQSFDAETQQ LLKTALKDPG AVDLERVANV IVDHSLQDCV FSKEAGRMCY
     AIIQAESKQA GQSVFRRGLL NRLQKEYDAR EQLRACSLQG WVCYVTFICN IFDYLRVNNM
     PMMALVNPVY DCLFQLAQPE SLSREEEVDC LVLQLHRVGE QLEKMNGQRM DELFILIRDG
     FLLPIDLSSL ARLLLLEIIE FRAAGWKTTP AAHKYYYSEV SD