ID   MI4GD_XENTR             Reviewed;         223 AA.
AC   Q28H63;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=MIF4G domain-containing protein;
GN   Name=mif4gd; ORFNames=TEgg122i01.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions in replication-dependent translation of histone
CC       mRNAs which differ from other eukaryotic mRNAs in that they do not end
CC       with a poly-A tail but a stem-loop. May participate in circularizing
CC       those mRNAs specifically enhancing their translation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with eif4g1, eif4g2 and slbp; probably tethered by
CC       SLBP to the 3'-end of mRNAs ending with the histone stem-loop, it also
CC       interacts with eif4g1 which is bound to their 5'-end. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MIF4GD family. {ECO:0000305}.
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DR   EMBL; CR761027; CAJ83660.1; -; mRNA.
DR   RefSeq; NP_001016440.1; NM_001016440.2.
DR   RefSeq; XP_012827222.1; XM_012971768.2.
DR   RefSeq; XP_012827223.1; XM_012971769.2.
DR   AlphaFoldDB; Q28H63; -.
DR   SMR; Q28H63; -.
DR   PaxDb; Q28H63; -.
DR   GeneID; 549194; -.
DR   KEGG; xtr:549194; -.
DR   CTD; 57409; -.
DR   Xenbase; XB-GENE-5757641; mif4gd.
DR   eggNOG; KOG3942; Eukaryota.
DR   InParanoid; Q28H63; -.
DR   OrthoDB; 1168859at2759; -.
DR   Proteomes; UP000008143; Chromosome 10.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000027063; Expressed in 2-cell stage embryo and 12 other tissues.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008494; F:translation activator activity; IBA:GO_Central.
DR   GO; GO:0006446; P:regulation of translational initiation; IBA:GO_Central.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   Pfam; PF02854; MIF4G; 1.
DR   SMART; SM00543; MIF4G; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Translation regulation.
FT   CHAIN           1..223
FT                   /note="MIF4G domain-containing protein"
FT                   /id="PRO_0000337096"
FT   DOMAIN          9..206
FT                   /note="MIF4G"
SQ   SEQUENCE   223 AA;  25835 MW;  67C902D302CB3168 CRC64;
     MADSEQQEDY KIQGFDADTQ SLLKTALKEP GSVDLEKAAS VIVDQSLRDA TFSREAGRMC
     YTIIQAESKQ TGRTVFRSTL LNRLQVEYKN RKETRARSLQ EWVCYVGFMC NVFDYLRVNN
     MPMLALVNPV YDCLFDLVQP DNLKREEEVD CLVLQLHRVG EQLEKMNCQR MDELFSQLRD
     SFLLQGGLSS LTQLLLLEMI EYRAAGWRMT DAAQKYYYSE VSE