ARLY_DESVH
ID ARLY_DESVH Reviewed; 460 AA.
AC Q72D36;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN Name=argH {ECO:0000255|HAMAP-Rule:MF_00006}; OrderedLocusNames=DVU_1094;
OS Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM
OS B-1760 / Hildenborough).
OC Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC Desulfovibrionaceae; Desulfovibrio.
OX NCBI_TaxID=882;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough;
RX PubMed=15077118; DOI=10.1038/nbt959;
RA Heidelberg J.F., Seshadri R., Haveman S.A., Hemme C.L., Paulsen I.T.,
RA Kolonay J.F., Eisen J.A., Ward N.L., Methe B.A., Brinkac L.M.,
RA Daugherty S.C., DeBoy R.T., Dodson R.J., Durkin A.S., Madupu R.,
RA Nelson W.C., Sullivan S.A., Fouts D.E., Haft D.H., Selengut J.,
RA Peterson J.D., Davidsen T.M., Zafar N., Zhou L., Radune D., Dimitrov G.,
RA Hance M., Tran K., Khouri H.M., Gill J., Utterback T.R., Feldblyum T.V.,
RA Wall J.D., Voordouw G., Fraser C.M.;
RT "The genome sequence of the anaerobic, sulfate-reducing bacterium
RT Desulfovibrio vulgaris Hildenborough.";
RL Nat. Biotechnol. 22:554-559(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00006};
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC Rule:MF_00006}.
CC -!- INTERACTION:
CC Q72D36; Q72AA6: thiE-1; NbExp=3; IntAct=EBI-10067699, EBI-10067695;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR EMBL; AE017285; AAS95574.1; -; Genomic_DNA.
DR RefSeq; WP_010938393.1; NZ_CABHLV010000001.1.
DR RefSeq; YP_010315.1; NC_002937.3.
DR AlphaFoldDB; Q72D36; -.
DR SMR; Q72D36; -.
DR IntAct; Q72D36; 2.
DR STRING; 882.DVU_1094; -.
DR PaxDb; Q72D36; -.
DR EnsemblBacteria; AAS95574; AAS95574; DVU_1094.
DR KEGG; dvu:DVU_1094; -.
DR PATRIC; fig|882.5.peg.1032; -.
DR eggNOG; COG0165; Bacteria.
DR HOGENOM; CLU_027272_2_3_7; -.
DR OMA; KKNPDVF; -.
DR PhylomeDB; Q72D36; -.
DR UniPathway; UPA00068; UER00114.
DR Proteomes; UP000002194; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR CDD; cd01359; Argininosuccinate_lyase; 1.
DR Gene3D; 1.10.275.10; -; 1.
DR HAMAP; MF_00006; Arg_succ_lyase; 1.
DR InterPro; IPR029419; Arg_succ_lyase_C.
DR InterPro; IPR009049; Argininosuccinate_lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR PANTHER; PTHR43814; PTHR43814; 1.
DR Pfam; PF14698; ASL_C2; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; SSF48557; 1.
DR TIGRFAMs; TIGR00838; argH; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 1: Evidence at protein level;
KW Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase;
KW Reference proteome.
FT CHAIN 1..460
FT /note="Argininosuccinate lyase"
FT /id="PRO_0000137767"
SQ SEQUENCE 460 AA; 51036 MW; 5EEF1C4AA740AD05 CRC64;
MAEKKMWGGR FKQGTATLVE EYTESVSYDR ALYAQDIAGS MAHARMLARQ GVLTAEEAAI
IVDGLATVRS EIEAGSFVWR REFEDVHMNI ENRLTELVGD VGKKLHTGRS RNDQVALDFR
LFVSDRVRVW RELGRDLVGV IVDQARQHTA TLLPGCTHMQ PAQPVSLAQH LLAYAWMLRR
DIDRLEDCDK RARVCPLGAA ALAGTTYPLD PASVADELGM YGTFRNSMDA VSDRDFVLEA
LFDGSVIMAH LSRLCEEFIL WANPAFGYIF LPDAYATGSS IMPQKKNPDV AELMRGKTGR
VYGALTTMLT TVKGLPMTYN RDLQEDKEPF IDADRTVSAS LEIMAGMLRE VRFNTARMRT
ALRSGFLNAT ELADYLVGKG IPFREAHHLT GAAVALAEEK GVTLEELPLE DYRGICDRID
EDVYPILEPE AAVSRRETPG GTGPRSVAAQ IAELDSWLGR
