ID   ARLY_GLOVI              Reviewed;         468 AA.
AC   Q7NLS0;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE            Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE            EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE   AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN   Name=argH {ECO:0000255|HAMAP-Rule:MF_00006}; OrderedLocusNames=gll1051;
OS   Gloeobacter violaceus (strain ATCC 29082 / PCC 7421).
OC   Bacteria; Cyanobacteria; Gloeobacteria; Gloeobacterales; Gloeobacteraceae;
OC   Gloeobacter.
OX   NCBI_TaxID=251221;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29082 / PCC 7421;
RX   PubMed=14621292; DOI=10.1093/dnares/10.4.137;
RA   Nakamura Y., Kaneko T., Sato S., Mimuro M., Miyashita H., Tsuchiya T.,
RA   Sasamoto S., Watanabe A., Kawashima K., Kishida Y., Kiyokawa C., Kohara M.,
RA   Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Takeuchi C., Yamada M.,
RA   Tabata S.;
RT   "Complete genome structure of Gloeobacter violaceus PCC 7421, a
RT   cyanobacterium that lacks thylakoids.";
RL   DNA Res. 10:137-145(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC         Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC         ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00006};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC       from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC       Rule:MF_00006}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR   EMBL; BA000045; BAC88992.1; -; Genomic_DNA.
DR   RefSeq; NP_923997.1; NC_005125.1.
DR   RefSeq; WP_011141053.1; NC_005125.1.
DR   AlphaFoldDB; Q7NLS0; -.
DR   SMR; Q7NLS0; -.
DR   STRING; 251221.35211614; -.
DR   EnsemblBacteria; BAC88992; BAC88992; BAC88992.
DR   KEGG; gvi:gll1051; -.
DR   PATRIC; fig|251221.4.peg.1077; -.
DR   eggNOG; COG0165; Bacteria.
DR   HOGENOM; CLU_027272_2_3_3; -.
DR   InParanoid; Q7NLS0; -.
DR   OMA; KKNPDVF; -.
DR   OrthoDB; 751464at2; -.
DR   PhylomeDB; Q7NLS0; -.
DR   UniPathway; UPA00068; UER00114.
DR   Proteomes; UP000000557; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IBA:GO_Central.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IBA:GO_Central.
DR   CDD; cd01359; Argininosuccinate_lyase; 1.
DR   Gene3D; 1.10.275.10; -; 1.
DR   HAMAP; MF_00006; Arg_succ_lyase; 1.
DR   InterPro; IPR029419; Arg_succ_lyase_C.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR020557; Fumarate_lyase_CS.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   PANTHER; PTHR43814; PTHR43814; 1.
DR   Pfam; PF14698; ASL_C2; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; SSF48557; 1.
DR   TIGRFAMs; TIGR00838; argH; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase;
KW   Reference proteome.
FT   CHAIN           1..468
FT                   /note="Argininosuccinate lyase"
FT                   /id="PRO_0000137774"
SQ   SEQUENCE   468 AA;  51677 MW;  C7E857AF828A85DD CRC64;
     MTATPWSARF EAGLHPTVAA FNASIGFDIE LIEYDLSGSA AHARMLAHSG ILSEAEAEAL
     VGGLEQIRSE WRTGQFRPGL EQEDVHYAVE RRLVELVGEV GKKLHTARSR NDQVGTDLRL
     WLRERIDRIV GRLGVFQRTL LDLAACHVET LIPGYTHLQR AQPVSLAHHL LAYIEMGERD
     IERLTQIRER VNVCPLGSGA LAGTVLPIDR HYTARLLGFV ALSENSLDAV SDRDYVVEFL
     AAASLIAVHL SRLSEEIILW ASQEFRFLTL TDRCATGSSL MPQKKNPDVP ELVRGKTGRI
     FGHLMGMLTV LKGLPLAYNK DLQEDKEGIF DAARSVESSL EAMTILMAEG IVFQPDRLAG
     AVEEDFSNAT DAADYLVRKG VPFREAYGVI GAVVKHCLKS NALLRDLPIA QWRHFHPAFD
     DDLYAAITPR TVVAARNSYG GTGFEQVRAA LGRAEARWQG HFPSASAH