ID   ARLY_HALSA              Reviewed;         485 AA.
AC   Q9HMQ3;
DT   23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 120.
DE   RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE            Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE            EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE   AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN   Name=argH {ECO:0000255|HAMAP-Rule:MF_00006}; OrderedLocusNames=VNG_2436G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC         Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC         ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00006};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC       from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC       Rule:MF_00006}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR   EMBL; AE004437; AAG20518.1; -; Genomic_DNA.
DR   PIR; B84394; B84394.
DR   RefSeq; WP_010903820.1; NC_002607.1.
DR   AlphaFoldDB; Q9HMQ3; -.
DR   SMR; Q9HMQ3; -.
DR   STRING; 64091.VNG_2436G; -.
DR   PaxDb; Q9HMQ3; -.
DR   EnsemblBacteria; AAG20518; AAG20518; VNG_2436G.
DR   GeneID; 5953385; -.
DR   KEGG; hal:VNG_2436G; -.
DR   PATRIC; fig|64091.14.peg.1886; -.
DR   HOGENOM; CLU_027272_2_3_2; -.
DR   InParanoid; Q9HMQ3; -.
DR   OMA; KKNPDVF; -.
DR   OrthoDB; 51806at2157; -.
DR   PhylomeDB; Q9HMQ3; -.
DR   UniPathway; UPA00068; UER00114.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IBA:GO_Central.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IBA:GO_Central.
DR   CDD; cd01359; Argininosuccinate_lyase; 1.
DR   Gene3D; 1.10.275.10; -; 1.
DR   HAMAP; MF_00006; Arg_succ_lyase; 1.
DR   InterPro; IPR029419; Arg_succ_lyase_C.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   PANTHER; PTHR43814; PTHR43814; 1.
DR   Pfam; PF14698; ASL_C2; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; SSF48557; 1.
DR   TIGRFAMs; TIGR00838; argH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase;
KW   Reference proteome.
FT   CHAIN           1..485
FT                   /note="Argininosuccinate lyase"
FT                   /id="PRO_0000137860"
SQ   SEQUENCE   485 AA;  48792 MW;  5C23512E63CBEA29 CRC64;
     MTGGGDPVVR RDRFSGGPAR SFLSSMDGDG RIFEADLAVD RAHVVMLAEQ DVIGDEAAAA
     ILGALADVEA AGFDALPPGE DVHEAIETAV VEAVGRDGGK LHTARSRNDE VAACIRYRLR
     ADLLDAIEVV VALRSALADV AAAEAETVMP GFTHLQPAQP TTVAHWALSY AGTLARDTGR
     LCDAYGRTNE SPLGAAAFAG TTFGVDRERT AALLGFDGVV ANAADAAASR DFLLEAVSAL
     ASVAVTCSGL AADVVFFANR GFVEVSDDYA STSSIMPQKK NPDTMELVRA TAGDAVGAQQ
     ALATTLQGLP RAYNRDLQRA TGHAWTAVDG VTSAVEVAAG VVATAGWPAD DLEAAAGEGF
     STATGVADAL AAGGLPFRTA HEVVALAAER GCEGATLDAV AAATEAVTGE PLSAVVEPAA
     VADALDPVGS VAARDSAGGP APAAVEAAVA DVRDGIDADE AALAAERASL ADAADALAAE
     VSGYV