ID   ARLY_HELMO              Reviewed;         458 AA.
AC   Q8GDU5;
DT   23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE            Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE            EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE   AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
DE   Flags: Fragment;
OS   Heliobacterium mobile (Heliobacillus mobilis).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Heliobacteriaceae;
OC   Heliobacterium.
OX   NCBI_TaxID=28064;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12446909; DOI=10.1126/science.1075558;
RA   Raymond J., Zhaxybayeva O., Gogarten J.P., Gerdes S.Y., Blankenship R.E.;
RT   "Whole-genome analysis of photosynthetic prokaryotes.";
RL   Science 298:1616-1620(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC         Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC         ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00006};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC       from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC       Rule:MF_00006}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY142879; AAN87483.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8GDU5; -.
DR   SMR; Q8GDU5; -.
DR   UniPathway; UPA00068; UER00114.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR   CDD; cd01359; Argininosuccinate_lyase; 1.
DR   Gene3D; 1.10.275.10; -; 1.
DR   HAMAP; MF_00006; Arg_succ_lyase; 1.
DR   InterPro; IPR029419; Arg_succ_lyase_C.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR020557; Fumarate_lyase_CS.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   PANTHER; PTHR43814; PTHR43814; 1.
DR   Pfam; PF14698; ASL_C2; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; SSF48557; 1.
DR   TIGRFAMs; TIGR00838; argH; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase.
FT   CHAIN           1..>458
FT                   /note="Argininosuccinate lyase"
FT                   /id="PRO_0000137778"
FT   NON_TER         458
SQ   SEQUENCE   458 AA;  51031 MW;  8A7ECE9F7E41C8AC CRC64;
     MSKKLWGGRF EKGTDKVVED FHSSIRFDQR LYKQDIRGSI AHARMLGRQG IIAASEAEQI
     IEGLEKIMAD IEAGRVEFDV AAEDIHMNIE KILTERIGDV GKKLHTGRSR NDQVALDVRL
     YLRDEITETG RLLRELITVL LERAEEHVDT IMPGYTHLQK AQPITLAHHL LAYVQMFGRD
     CSRLVDCAKR FNISPLGSGA LAGTTFPLDR MAVAQELGFD GITENSLDGV SDRDFAIEFC
     GAASLIMMHL SRFCEEIILW SSQEFSFIEL DDAYSTGSSM MPQKKNPDVA ELIRGKTGRV
     YGDLMALLTV MKSLPLAYNK DMQEDKENLF DAVDTVKGCL AVFTPMIRTM RVRGERMKAG
     AKGGFTNATD VADYLAKKGV SFREAHEIVG KMVLMCVQKS VALEDLSFED FRACSEAFEE
     DVFDAIRVER CVADRKVPGG PAPDAVKAAI QAARERLS