6PGL1_ARATH
ID 6PGL1_ARATH Reviewed; 268 AA.
AC Q9LMX8;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Probable 6-phosphogluconolactonase 1 {ECO:0000305};
DE Short=6PGL1 {ECO:0000305};
DE EC=3.1.1.31 {ECO:0000250|UniProtKB:Q84WW2};
GN Name=PGL1 {ECO:0000303|PubMed:19457984};
GN OrderedLocusNames=At1g13700 {ECO:0000312|Araport:AT1G13700};
GN ORFNames=F21F23.14 {ECO:0000312|EMBL:AAF81297.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, NOMENCLATURE, AND DISRUPTION PHENOTYPE.
RX PubMed=19457984; DOI=10.1093/pcp/pcp070;
RA Xiong Y., DeFraia C., Williams D., Zhang X., Mou Z.;
RT "Characterization of Arabidopsis 6-phosphogluconolactonase T-DNA insertion
RT mutants reveals an essential role for the oxidative section of the
RT plastidic pentose phosphate pathway in plant growth and development.";
RL Plant Cell Physiol. 50:1277-1291(2009).
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=24008768; DOI=10.1093/mp/sst126;
RA Hoelscher C., Meyer T., von Schaewen A.;
RT "Dual-targeting of Arabidopsis 6-phosphogluconolactonase 3 (PGL3) to
RT chloroplasts and peroxisomes involves interaction with Trx m2 in the
RT cytosol.";
RL Mol. Plant 7:252-255(2014).
CC -!- FUNCTION: Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-
CC phosphogluconate. {ECO:0000250|UniProtKB:Q84WW2}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate
CC + H(+); Xref=Rhea:RHEA:12556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57955, ChEBI:CHEBI:58759; EC=3.1.1.31;
CC Evidence={ECO:0000250|UniProtKB:Q84WW2};
CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC 2/3. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:24008768}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions. {ECO:0000269|PubMed:19457984}.
CC -!- SIMILARITY: Belongs to the glucosamine/galactosamine-6-phosphate
CC isomerase family. 6-phosphogluconolactonase subfamily. {ECO:0000305}.
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DR EMBL; AC027656; AAF81297.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29059.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM59247.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM59248.1; -; Genomic_DNA.
DR EMBL; BT014903; AAT46032.1; -; mRNA.
DR EMBL; BT015753; AAU84690.1; -; mRNA.
DR PIR; D86270; D86270.
DR RefSeq; NP_001318995.1; NM_001332082.1.
DR RefSeq; NP_001321621.1; NM_001332083.1.
DR RefSeq; NP_172826.1; NM_101239.4.
DR AlphaFoldDB; Q9LMX8; -.
DR SMR; Q9LMX8; -.
DR STRING; 3702.AT1G13700.1; -.
DR PaxDb; Q9LMX8; -.
DR PRIDE; Q9LMX8; -.
DR ProteomicsDB; 245137; -.
DR EnsemblPlants; AT1G13700.1; AT1G13700.1; AT1G13700.
DR EnsemblPlants; AT1G13700.2; AT1G13700.2; AT1G13700.
DR EnsemblPlants; AT1G13700.3; AT1G13700.3; AT1G13700.
DR GeneID; 837931; -.
DR Gramene; AT1G13700.1; AT1G13700.1; AT1G13700.
DR Gramene; AT1G13700.2; AT1G13700.2; AT1G13700.
DR Gramene; AT1G13700.3; AT1G13700.3; AT1G13700.
DR KEGG; ath:AT1G13700; -.
DR Araport; AT1G13700; -.
DR TAIR; locus:2023842; AT1G13700.
DR eggNOG; KOG3147; Eukaryota.
DR HOGENOM; CLU_053947_0_0_1; -.
DR InParanoid; Q9LMX8; -.
DR OMA; YQLFEFE; -.
DR OrthoDB; 1420529at2759; -.
DR PhylomeDB; Q9LMX8; -.
DR BioCyc; ARA:AT1G13700-MON; -.
DR BRENDA; 3.1.1.31; 399.
DR UniPathway; UPA00115; UER00409.
DR PRO; PR:Q9LMX8; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LMX8; baseline and differential.
DR Genevisible; Q9LMX8; AT.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0017057; F:6-phosphogluconolactonase activity; IBA:GO_Central.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0009051; P:pentose-phosphate shunt, oxidative branch; IBA:GO_Central.
DR CDD; cd01400; 6PGL; 1.
DR InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR InterPro; IPR039104; PGLS.
DR PANTHER; PTHR11054; PTHR11054; 1.
DR Pfam; PF01182; Glucosamine_iso; 1.
DR SUPFAM; SSF100950; SSF100950; 1.
DR TIGRFAMs; TIGR01198; pgl; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Hydrolase; Reference proteome.
FT CHAIN 1..268
FT /note="Probable 6-phosphogluconolactonase 1"
FT /id="PRO_0000288668"
SQ SEQUENCE 268 AA; 29887 MW; BF11D4FAC1E81294 CRC64;
MALTWTHKDR GEIRVHENLE ELSIDLVDYI AEISEASIKE HGAFCIVLSG GSLISFMGKL
IEPPYDKIVD WAKWYVFWAD ERVVAKNHDD SNYKLAKDNL LSKVNVFPRH ICSINDTVSA
EEAATEYEFA IRQMVRSRTV AASDNSDSPR FDLILLGMGS DGHVASLFPN HPALEVKDDW
VTFLTDSHKP PPERITFTLP VINSAANVVV VATGESKANA IHLAIDDLPL PDSSLSLPAR
LVHPSNGNLI WFMDKQAGSK LDRFKFSE
