ID   ARLY_LACLA              Reviewed;         459 AA.
AC   Q9CJ76;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 1.
DT   25-MAY-2022, entry version 124.
DE   RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE            Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE            EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE   AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN   Name=argH {ECO:0000255|HAMAP-Rule:MF_00006}; OrderedLocusNames=LL0125;
GN   ORFNames=L0114;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC         Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC         ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00006};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC       from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC       Rule:MF_00006}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR   EMBL; AE005176; AAK04223.1; -; Genomic_DNA.
DR   PIR; E86640; E86640.
DR   RefSeq; NP_266281.1; NC_002662.1.
DR   RefSeq; WP_010905136.1; NC_002662.1.
DR   AlphaFoldDB; Q9CJ76; -.
DR   SMR; Q9CJ76; -.
DR   STRING; 272623.L0114; -.
DR   PaxDb; Q9CJ76; -.
DR   EnsemblBacteria; AAK04223; AAK04223; L0114.
DR   KEGG; lla:L0114; -.
DR   PATRIC; fig|272623.7.peg.138; -.
DR   eggNOG; COG0165; Bacteria.
DR   HOGENOM; CLU_027272_2_3_9; -.
DR   OMA; KKNPDVF; -.
DR   UniPathway; UPA00068; UER00114.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR   CDD; cd01359; Argininosuccinate_lyase; 1.
DR   Gene3D; 1.10.275.10; -; 1.
DR   HAMAP; MF_00006; Arg_succ_lyase; 1.
DR   InterPro; IPR029419; Arg_succ_lyase_C.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR020557; Fumarate_lyase_CS.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   PANTHER; PTHR43814; PTHR43814; 1.
DR   Pfam; PF14698; ASL_C2; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; SSF48557; 1.
DR   TIGRFAMs; TIGR00838; argH; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase;
KW   Reference proteome.
FT   CHAIN           1..459
FT                   /note="Argininosuccinate lyase"
FT                   /id="PRO_0000137780"
SQ   SEQUENCE   459 AA;  51900 MW;  85D14D00AE622426 CRC64;
     MVEKLWGGRF EASLDKQTEE FGASIKFEQR LAPFDLKGSL AHVKMLGETG IITTEESKKI
     AEGLKKVEEK LLNGQIEFKM ENEDIHMNME SYLHQEIGPL AGKLHTARSR NDQVVTDMHL
     YLKSILEAVL EALKVLRETI VKLAVNQIDT IMPGYTHLQH AQPISFGQHL MAYYQMLTRD
     FERFEFNVKH TDMNPLGAAA LAGTTFPIDR MLTTKLLGFE KAYDNSMDAV SDRDFILEFL
     SNASLLMMHL SRFCEELLLW SSHEFKFVSL SDTYSTGSSI MPQKKNPDMA ELIRGKTGRV
     YGNLTALLTV MKGLPLAYNK DFQEDKEGMF DSADTIITSL TVMNGMLSTL TVNRVNMEKS
     TEQDFSNATE LADYLATKGL PFRKAHELVG LLVLDCIKKG IYLQDVNLQD YQMLSPLINE
     DVYEVLKSRT AVSRRNSLGG TGFESVKKQI EEAKKELQI