11S2_SESIN
ID 11S2_SESIN Reviewed; 459 AA.
AC Q9XHP0;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=11S globulin seed storage protein 2;
DE AltName: Full=11S globulin Ses i 6 {ECO:0000303|PubMed:17517107};
DE AltName: Full=11S globulin seed storage protein II;
DE AltName: Full=Allergen Ses i 6 {ECO:0000303|PubMed:17556061};
DE AltName: Full=Alpha-globulin;
DE AltName: Allergen=Ses i 6.0101 {ECO:0000305};
DE Contains:
DE RecName: Full=11S globulin seed storage protein 2 acidic chain;
DE AltName: Full=11S globulin seed storage protein II acidic chain;
DE Contains:
DE RecName: Full=11S globulin seed storage protein 2 basic chain;
DE AltName: Full=11S globulin seed storage protein II basic chain;
DE Flags: Precursor;
OS Sesamum indicum (Oriental sesame) (Sesamum orientale).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Pedaliaceae; Sesamum.
OX NCBI_TaxID=4182;
RN [1] {ECO:0000312|EMBL:AAD42944.1}
RP NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC STRAIN=cv. Tainan 1 {ECO:0000303|PubMed:10606554};
RC TISSUE=Seed {ECO:0000269|PubMed:10606554};
RX PubMed=10606554; DOI=10.1021/jf990366z;
RA Tai S.S.K., Wu L.S.H., Chen E.C.F., Tzen J.T.C.;
RT "Molecular cloning of 11S globulin and 2S albumin, the two major seed
RT storage proteins in sesame.";
RL J. Agric. Food Chem. 47:4932-4938(1999).
RN [2]
RP TISSUE SPECIFICITY, AND ALLERGEN.
RX PubMed=17517107; DOI=10.1111/j.1365-2222.2007.02725.x;
RA Wallowitz M.L., Chen R.J., Tzen J.T., Teuber S.S.;
RT "Ses i 6, the sesame 11S globulin, can activate basophils and shows cross-
RT reactivity with walnut in vitro.";
RL Clin. Exp. Allergy 37:929-938(2007).
RN [3]
RP TISSUE SPECIFICITY, AND ALLERGEN.
RX PubMed=17556061; DOI=10.1016/j.jaci.2007.03.041;
RA Beyer K., Grishina G., Bardina L., Sampson H.A.;
RT "Identification of 2 new sesame seed allergens: Ses i 6 and Ses i 7.";
RL J. Allergy Clin. Immunol. 119:1554-1556(2007).
CC -!- FUNCTION: Seed storage protein. {ECO:0000305|PubMed:10606554,
CC ECO:0000305|PubMed:17517107}.
CC -!- SUBUNIT: Homohexamer (By similarity). Each subunit is composed of an
CC acidic and a basic chain derived from a single precursor and linked by
CC a disulfide bond (PubMed:10606554). {ECO:0000250|UniProtKB:A0A1L6K371,
CC ECO:0000269|PubMed:10606554}.
CC -!- TISSUE SPECIFICITY: Expressed in seeds (at protein level)
CC (PubMed:10606554, PubMed:17517107). Expressed in seeds
CC (PubMed:17556061). {ECO:0000269|PubMed:10606554,
CC ECO:0000269|PubMed:17517107, ECO:0000269|PubMed:17556061}.
CC -!- DEVELOPMENTAL STAGE: Expressed during seed maturation. Expressed in the
CC maturing seeds 24 days after flowering. {ECO:0000269|PubMed:10606554}.
CC -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE of
CC patients allergic to sesame seeds (PubMed:17517107, PubMed:17556061).
CC Recombinant protein binds to IgE in 58% of the 19 patients tested
CC (PubMed:17517107). Recombinant protein binds strongly to IgE in 54% of
CC the 24 patients tested (PubMed:17556061). Recombinant protein is able
CC to activate basophils previously passively sensitized with sesame-
CC allergic sera in 7 out of 11 patients (PubMed:17517107).
CC {ECO:0000269|PubMed:17517107, ECO:0000269|PubMed:17556061}.
CC -!- SIMILARITY: Belongs to the 11S seed storage protein (globulins) family.
CC {ECO:0000255}.
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DR EMBL; AF091842; AAD42944.1; -; mRNA.
DR RefSeq; NP_001291336.1; NM_001304407.1.
DR AlphaFoldDB; Q9XHP0; -.
DR SMR; Q9XHP0; -.
DR Allergome; 2681; Ses i 6.
DR Allergome; 3476; Ses i 6.0101.
DR EnsemblPlants; SIN_1009682.t; SIN_1009682.t; SIN_1009682.
DR GeneID; 105163414; -.
DR Gramene; SIN_1009682.t; SIN_1009682.t; SIN_1009682.
DR KEGG; sind:105163414; -.
DR OrthoDB; 603461at2759; -.
DR PhylomeDB; Q9XHP0; -.
DR Proteomes; UP000504604; Linkage group LG6.
DR GO; GO:0042735; C:protein body; NAS:UniProtKB.
DR GO; GO:0045735; F:nutrient reservoir activity; NAS:UniProtKB.
DR GO; GO:0010431; P:seed maturation; IEP:UniProtKB.
DR Gene3D; 2.60.120.10; -; 2.
DR InterPro; IPR022379; 11S_seedstore_CS.
DR InterPro; IPR006044; 11S_seedstore_pln.
DR InterPro; IPR006045; Cupin_1.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR Pfam; PF00190; Cupin_1; 2.
DR PRINTS; PR00439; 11SGLOBULIN.
DR SMART; SM00835; Cupin_1; 2.
DR SUPFAM; SSF51182; SSF51182; 1.
DR PROSITE; PS00305; 11S_SEED_STORAGE; 1.
PE 1: Evidence at protein level;
KW Allergen; Disulfide bond; Reference proteome; Seed storage protein; Signal;
KW Storage protein.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..277
FT /note="11S globulin seed storage protein 2 acidic chain"
FT /evidence="ECO:0000250"
FT /id="PRO_0000043209"
FT CHAIN 278..459
FT /note="11S globulin seed storage protein 2 basic chain"
FT /evidence="ECO:0000250"
FT /id="PRO_0000043210"
FT DOMAIN 37..237
FT /note="Cupin type-1 1"
FT /evidence="ECO:0000255"
FT DOMAIN 290..439
FT /note="Cupin type-1 2"
FT /evidence="ECO:0000255"
FT REGION 118..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 34..67
FT /evidence="ECO:0000250"
FT DISULFID 110..284
FT /note="Interchain (between acidic and basic chains)"
FT /evidence="ECO:0000250|UniProtKB:P04405"
SQ SEQUENCE 459 AA; 51830 MW; E852F6C47B319200 CRC64;
MVAFKFLLAL SLSLLVSAAI AQTREPRLTQ GQQCRFQRIS GAQPSLRIQS EGGTTELWDE
RQEQFQCAGI VAMRSTIRPN GLSLPNYHPS PRLVYIERGQ GLISIMVPGC AETYQVHRSQ
RTMERTEASE QQDRGSVRDL HQKVHRLRQG DIVAIPSGAA HWCYNDGSED LVAVSINDVN
HLSNQLDQKF RAFYLAGGVP RSGEQEQQAR QTFHNIFRAF DAELLSEAFN VPQETIRRMQ
SEEEERGLIV MARERMTFVR PDEEEGEQEH RGRQLDNGLE ETFCTMKFRT NVESRREADI
FSRQAGRVHV VDRNKLPILK YMDLSAEKGN LYSNALVSPD WSMTGHTIVY VTRGDAQVQV
VDHNGQALMN DRVNQGEMFV VPQYYTSTAR AGNNGFEWVA FKTTGSPMRS PLAGYTSVIR
AMPLQVITNS YQISPNQAQA LKMNRGSQSF LLSPGGRRS
