6PGL2_ARATH
ID 6PGL2_ARATH Reviewed; 259 AA.
AC Q8LG70; Q9SG13;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Probable 6-phosphogluconolactonase 2 {ECO:0000305};
DE Short=6PGL2 {ECO:0000305};
DE EC=3.1.1.31 {ECO:0000250|UniProtKB:Q84WW2};
GN Name=PGL2 {ECO:0000303|PubMed:19457984};
GN OrderedLocusNames=At3g49360 {ECO:0000312|Araport:AT3G49360};
GN ORFNames=F2K15.220 {ECO:0000312|EMBL:CAB66415.1},
GN T1G12.6 {ECO:0000312|EMBL:AAG52194.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY, NOMENCLATURE, AND DISRUPTION PHENOTYPE.
RX PubMed=19457984; DOI=10.1093/pcp/pcp070;
RA Xiong Y., DeFraia C., Williams D., Zhang X., Mou Z.;
RT "Characterization of Arabidopsis 6-phosphogluconolactonase T-DNA insertion
RT mutants reveals an essential role for the oxidative section of the
RT plastidic pentose phosphate pathway in plant growth and development.";
RL Plant Cell Physiol. 50:1277-1291(2009).
RN [7]
RP SUBCELLULAR LOCATION.
RX PubMed=24008768; DOI=10.1093/mp/sst126;
RA Hoelscher C., Meyer T., von Schaewen A.;
RT "Dual-targeting of Arabidopsis 6-phosphogluconolactonase 3 (PGL3) to
RT chloroplasts and peroxisomes involves interaction with Trx m2 in the
RT cytosol.";
RL Mol. Plant 7:252-255(2014).
CC -!- FUNCTION: Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-
CC phosphogluconate. {ECO:0000250|UniProtKB:Q84WW2}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate
CC + H(+); Xref=Rhea:RHEA:12556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57955, ChEBI:CHEBI:58759; EC=3.1.1.31;
CC Evidence={ECO:0000250|UniProtKB:Q84WW2};
CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC 2/3. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:24008768}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions. {ECO:0000269|PubMed:19457984}.
CC -!- SIMILARITY: Belongs to the glucosamine/galactosamine-6-phosphate
CC isomerase family. 6-phosphogluconolactonase subfamily. {ECO:0000305}.
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DR EMBL; AC012329; AAG52194.1; -; Genomic_DNA.
DR EMBL; AL132956; CAB66415.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE78532.1; -; Genomic_DNA.
DR EMBL; AK117146; BAC41824.1; -; mRNA.
DR EMBL; AY084434; AAM61007.1; -; mRNA.
DR EMBL; BT024902; ABD91493.1; -; mRNA.
DR PIR; T45841; T45841.
DR RefSeq; NP_190505.1; NM_114796.4.
DR AlphaFoldDB; Q8LG70; -.
DR SMR; Q8LG70; -.
DR STRING; 3702.AT3G49360.1; -.
DR PaxDb; Q8LG70; -.
DR PRIDE; Q8LG70; -.
DR ProteomicsDB; 245160; -.
DR EnsemblPlants; AT3G49360.1; AT3G49360.1; AT3G49360.
DR GeneID; 824098; -.
DR Gramene; AT3G49360.1; AT3G49360.1; AT3G49360.
DR KEGG; ath:AT3G49360; -.
DR Araport; AT3G49360; -.
DR TAIR; locus:2082916; AT3G49360.
DR eggNOG; KOG3147; Eukaryota.
DR HOGENOM; CLU_053947_0_0_1; -.
DR InParanoid; Q8LG70; -.
DR OMA; ERVCAWD; -.
DR OrthoDB; 1420529at2759; -.
DR PhylomeDB; Q8LG70; -.
DR BioCyc; ARA:AT3G49360-MON; -.
DR BRENDA; 3.1.1.31; 399.
DR UniPathway; UPA00115; UER00409.
DR PRO; PR:Q8LG70; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q8LG70; baseline and differential.
DR Genevisible; Q8LG70; AT.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR GO; GO:0017057; F:6-phosphogluconolactonase activity; IBA:GO_Central.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0009051; P:pentose-phosphate shunt, oxidative branch; IBA:GO_Central.
DR CDD; cd01400; 6PGL; 1.
DR InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR InterPro; IPR039104; PGLS.
DR PANTHER; PTHR11054; PTHR11054; 1.
DR Pfam; PF01182; Glucosamine_iso; 1.
DR SUPFAM; SSF100950; SSF100950; 1.
DR TIGRFAMs; TIGR01198; pgl; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Hydrolase; Reference proteome.
FT CHAIN 1..259
FT /note="Probable 6-phosphogluconolactonase 2"
FT /id="PRO_0000288669"
FT CONFLICT 35
FT /note="G -> E (in Ref. 4; AAM61007)"
FT /evidence="ECO:0000305"
FT CONFLICT 42
FT /note="S -> Y (in Ref. 4; AAM61007)"
FT /evidence="ECO:0000305"
FT CONFLICT 99
FT /note="V -> I (in Ref. 4; AAM61007)"
FT /evidence="ECO:0000305"
FT CONFLICT 108
FT /note="D -> N (in Ref. 4; AAM61007)"
FT /evidence="ECO:0000305"
FT CONFLICT 194
FT /note="L -> F (in Ref. 4; AAM61007)"
FT /evidence="ECO:0000305"
FT CONFLICT 218
FT /note="V -> A (in Ref. 4; AAM61007)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 259 AA; 28863 MW; DA9C421E48BC0CA6 CRC64;
MAPVKRRVFK TNNEMAVELA KYTADLSSKF CKERGVFTVV LSGGDLIAWL WKLLEAPYID
SIEWSKWHIF WVDERVCAWD HADSNYKLAY DGFLSKVPVP AENIYAIDNG LGAEGNAELA
AERYEECLKQ KVNQNIIRTY KSSGFPQFDL QLLGMGPDGH MASLFPGHAQ INEKVKWVTS
ITDSPKPPSK RITLTLPVIN CASYNVMAVC DKEQADSVAA ALNHTKDLPA GRLTADVEVV
WFLDQAAASK LPHGWCSIL
