ARLY_METAR
ID ARLY_METAR Reviewed; 497 AA.
AC Q0W7A4;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN Name=argH {ECO:0000255|HAMAP-Rule:MF_00006}; OrderedLocusNames=UNCMA_24420;
GN ORFNames=RCIX271;
OS Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanocellales; Methanocellaceae; Methanocella.
OX NCBI_TaxID=351160;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 22066 / NBRC 105507 / MRE50;
RX PubMed=16857943; DOI=10.1126/science.1127062;
RA Erkel C., Kube M., Reinhardt R., Liesack W.;
RT "Genome of rice cluster I archaea -- the key methane producers in the rice
RT rhizosphere.";
RL Science 313:370-372(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00006};
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC Rule:MF_00006}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR EMBL; AM114193; CAJ35739.1; -; Genomic_DNA.
DR RefSeq; WP_012036760.1; NC_009464.1.
DR AlphaFoldDB; Q0W7A4; -.
DR SMR; Q0W7A4; -.
DR STRING; 351160.RCIX271; -.
DR PRIDE; Q0W7A4; -.
DR EnsemblBacteria; CAJ35739; CAJ35739; RCIX271.
DR GeneID; 5144017; -.
DR KEGG; rci:RCIX271; -.
DR PATRIC; fig|351160.9.peg.2495; -.
DR eggNOG; arCOG01748; Archaea.
DR OMA; KKNPDVF; -.
DR OrthoDB; 51806at2157; -.
DR UniPathway; UPA00068; UER00114.
DR Proteomes; UP000000663; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR CDD; cd01359; Argininosuccinate_lyase; 1.
DR Gene3D; 1.10.275.10; -; 1.
DR HAMAP; MF_00006; Arg_succ_lyase; 1.
DR InterPro; IPR029419; Arg_succ_lyase_C.
DR InterPro; IPR009049; Argininosuccinate_lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR PANTHER; PTHR43814; PTHR43814; 1.
DR Pfam; PF14698; ASL_C2; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; SSF48557; 1.
DR TIGRFAMs; TIGR00838; argH; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase;
KW Reference proteome.
FT CHAIN 1..497
FT /note="Argininosuccinate lyase"
FT /id="PRO_0000321462"
SQ SEQUENCE 497 AA; 54696 MW; C838667380BF8663 CRC64;
MENKEDILRR GRLAAEKKKE VGEFTASIPA DRWLFPSDLL VDKAHTVMLA RQGIIAKEDA
AAILKALAAI EHEGVDAVNI PAFEDVHMAI ESKLIKAVGE NAGGRMHSGR SRNDEVATCI
RISARKELLG LMADLQDLRS ALLALAEEHK ETLMPGFTHL QHAQPTTLAH HMLAHASSFG
RDFERLADAL KFVNISPLGS AAFASTGYNL DRDLTAKLLG FDRPMDNSMD GVSARDFILD
LTSRMAIIEV NLSRLADELV LWSTSEFGFI ELSDTYASTS SIMPQKKNPD VLELVRGRSG
TVIGHMMAAF TIVKGLPYSY NSDLQEVTPQ LLRAFEITRS SVRIMAGAIQ TITVKKEEMR
RKSTMGFTTA TEIADTIVRS TGLPFRTAHG IVGRLAREGG NPSLADVDRA SVEMIGKKVS
EMGLTEKMVE EAKDPWSNVE RRSIVGGPAL KTVEKKISTE RKKMLLDAAL LSKMNDSLEE
AYRSLDREVR SMTEGQE
