ID   ARLY_METBF              Reviewed;         491 AA.
AC   Q46GJ5;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE            Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE            EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE   AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN   Name=argH {ECO:0000255|HAMAP-Rule:MF_00006}; OrderedLocusNames=Mbar_A0004;
OS   Methanosarcina barkeri (strain Fusaro / DSM 804).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=269797;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fusaro / DSM 804;
RX   PubMed=16980466; DOI=10.1128/jb.00810-06;
RA   Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S.,
RA   Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.;
RT   "The Methanosarcina barkeri genome: comparative analysis with
RT   Methanosarcina acetivorans and Methanosarcina mazei reveals extensive
RT   rearrangement within methanosarcinal genomes.";
RL   J. Bacteriol. 188:7922-7931(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC         Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC         ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00006};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC       from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC       Rule:MF_00006}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR   EMBL; CP000099; AAZ68997.1; -; Genomic_DNA.
DR   RefSeq; WP_011305052.1; NC_007355.1.
DR   AlphaFoldDB; Q46GJ5; -.
DR   SMR; Q46GJ5; -.
DR   STRING; 269797.Mbar_A0004; -.
DR   PRIDE; Q46GJ5; -.
DR   EnsemblBacteria; AAZ68997; AAZ68997; Mbar_A0004.
DR   GeneID; 3627590; -.
DR   KEGG; mba:Mbar_A0004; -.
DR   eggNOG; arCOG01748; Archaea.
DR   HOGENOM; CLU_027272_2_3_2; -.
DR   OMA; KKNPDVF; -.
DR   OrthoDB; 51806at2157; -.
DR   UniPathway; UPA00068; UER00114.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR   CDD; cd01359; Argininosuccinate_lyase; 1.
DR   Gene3D; 1.10.275.10; -; 1.
DR   HAMAP; MF_00006; Arg_succ_lyase; 1.
DR   InterPro; IPR029419; Arg_succ_lyase_C.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   PANTHER; PTHR43814; PTHR43814; 1.
DR   Pfam; PF14698; ASL_C2; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; SSF48557; 1.
DR   TIGRFAMs; TIGR00838; argH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase.
FT   CHAIN           1..491
FT                   /note="Argininosuccinate lyase"
FT                   /id="PRO_0000240790"
SQ   SEQUENCE   491 AA;  55075 MW;  D6742CB6FE0EB292 CRC64;
     MSNILRRGRL EAAQDEEILR YTSSMEADRW IFDADIAVDL AHTVMLKEQG IINREDCSKI
     LSGLLKIREE GMEKLDFSYE DIHISLESRL IDMVGEDVGG RMHSGRSRND EVATCIRLVL
     REELTGLLEE IHELRQALLT LAEKHTETLM PGFTHMQHAQ PTTLAHHLCA HEAALGRDFD
     RIQDAYSRVN LCPLGAAAFA STGFNLNRKR TQELLGFDGL LENSMDAVST RDFLIECASG
     FTNLMINLSR MAEELVIWSS SEFNFIELDD MYASTSSIMP QKKNPDTAEL MRGKTGVAVG
     ALMSLITICK GLPLSYNRDL QEATPNLWRS VETVRASVRI MEGMIKTMKV RPEVLVAQSV
     TGFTTATELA DTFVRETGIP FRTAHQIVGM LAREMEKPTL KKIDSVAEIV LGESLSSRGL
     KEKMVKEALN PFSNVEIRKI AGGPAPEEMR NYLSKRQTEL ELNRQEIATL KDITDSAFEN
     LLATVNEYRQ A