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ARLY_METKA
ID   ARLY_METKA              Reviewed;         508 AA.
AC   Q8TXN9;
DT   15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE            Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE            EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE   AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN   Name=argH {ECO:0000255|HAMAP-Rule:MF_00006}; OrderedLocusNames=MK0622;
OS   Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938).
OC   Archaea; Euryarchaeota; Methanopyri; Methanopyrales; Methanopyraceae;
OC   Methanopyrus.
OX   NCBI_TaxID=190192;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AV19 / DSM 6324 / JCM 9639 / NBRC 100938;
RX   PubMed=11930014; DOI=10.1073/pnas.032671499;
RA   Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N.,
RA   Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A.,
RA   Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G.,
RA   Koonin E.V., Kozyavkin S.A.;
RT   "The complete genome of hyperthermophile Methanopyrus kandleri AV19 and
RT   monophyly of archaeal methanogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC         Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC         ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00006};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC       from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC       Rule:MF_00006}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR   EMBL; AE009439; AAM01837.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8TXN9; -.
DR   SMR; Q8TXN9; -.
DR   STRING; 190192.MK0622; -.
DR   PRIDE; Q8TXN9; -.
DR   EnsemblBacteria; AAM01837; AAM01837; MK0622.
DR   KEGG; mka:MK0622; -.
DR   HOGENOM; CLU_027272_2_0_2; -.
DR   OMA; KKNPDVF; -.
DR   UniPathway; UPA00068; UER00114.
DR   Proteomes; UP000001826; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR   CDD; cd01359; Argininosuccinate_lyase; 1.
DR   Gene3D; 1.10.275.10; -; 1.
DR   HAMAP; MF_00006; Arg_succ_lyase; 1.
DR   InterPro; IPR029419; Arg_succ_lyase_C.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   PANTHER; PTHR43814; PTHR43814; 1.
DR   Pfam; PF14698; ASL_C2; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; SSF48557; 1.
DR   TIGRFAMs; TIGR00838; argH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase;
KW   Reference proteome.
FT   CHAIN           1..508
FT                   /note="Argininosuccinate lyase"
FT                   /id="PRO_0000137863"
SQ   SEQUENCE   508 AA;  55635 MW;  2838F8287E0ABE68 CRC64;
     MALGRPSYRG GRVSGGRDPD FAELSSSLEQ DREIFHCDVW NSVVHAVSLW EAGRIDRSTA
     AGIVEGLVTV LEEGPDRLPE DAEDVHEAIE SRLHEVVGEE AGWLQLGRSR NDQVATSVRM
     RLRERALDLS RELVGLGRAL LDLAREHAEV PIAGYTHLKR AQPCTIGFWM STYAAAVARS
     ARGLLRVPGM DECPLGCSAF PGSTVPVDRH REAALLGFRK PARHCGEATA LRGPILEFLG
     RLATAASELT RLAGDLIQLC SDELGVVEPP DELSSTSSVM PHKKNPDALE LVRAELTVVA
     GLKGLGDAVH GKLPMFYNRD LQVLNGLLWD SVNRFELCVR VLRKVVEGLD VDEEAARGTV
     LGSHAAAVDL AELVAERAGL TFREAHKVVG RVSARLDREG VPMSPERADR VVEELEREGV
     KLRVEEVREV LSLKRTLRRP VEGSTDPGRL EVTLDRLRAE LAAAERLEGT WRGRIERALR
     ATEAAVNRLG VEGFAEVYRG YWDGEAPG
 
 
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