ARLY_METM7
ID ARLY_METM7 Reviewed; 481 AA.
AC A6VI01;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN Name=argH {ECO:0000255|HAMAP-Rule:MF_00006}; OrderedLocusNames=MmarC7_1010;
OS Methanococcus maripaludis (strain C7 / ATCC BAA-1331).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=426368;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C7 / ATCC BAA-1331;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Anderson I., Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT "Complete sequence of Methanococcus maripaludis C7.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00006};
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC Rule:MF_00006}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR EMBL; CP000745; ABR66077.1; -; Genomic_DNA.
DR RefSeq; WP_011977390.1; NC_009637.1.
DR AlphaFoldDB; A6VI01; -.
DR SMR; A6VI01; -.
DR STRING; 426368.MmarC7_1010; -.
DR EnsemblBacteria; ABR66077; ABR66077; MmarC7_1010.
DR GeneID; 5328479; -.
DR KEGG; mmz:MmarC7_1010; -.
DR eggNOG; arCOG01748; Archaea.
DR HOGENOM; CLU_027272_2_3_2; -.
DR OMA; KKNPDVF; -.
DR OrthoDB; 51806at2157; -.
DR UniPathway; UPA00068; UER00114.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR CDD; cd01359; Argininosuccinate_lyase; 1.
DR Gene3D; 1.10.275.10; -; 1.
DR HAMAP; MF_00006; Arg_succ_lyase; 1.
DR InterPro; IPR029419; Arg_succ_lyase_C.
DR InterPro; IPR009049; Argininosuccinate_lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR PANTHER; PTHR43814; PTHR43814; 1.
DR Pfam; PF14698; ASL_C2; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; SSF48557; 1.
DR TIGRFAMs; TIGR00838; argH; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase.
FT CHAIN 1..481
FT /note="Argininosuccinate lyase"
FT /id="PRO_1000000501"
SQ SEQUENCE 481 AA; 54274 MW; C12B19FA5786D925 CRC64;
MNILRRGRLG SNVKEDVMKF TTSLEFDKEI FESDILCDIA HTTMLIEQNV ISEENGKKII
AELKKIAEKG MENLDLDPSL DDIHMVIESE LIKELGEDVA GRMHTGRSRN DEVATDLRLS
LRKKVLEIIG HLITMEQNML KVSNEHKETL TVGYTHLQQA QPVTFGHHIL SHVSAIERDI
SRFFDTYNRI NISPLGCSAM ATTGFNLNRK RTQELLGFYD IIENSMDGVS SRDFIVETMA
NISMLGTNLS KICEELVVFS SAEFNTIEIA NEYTSTSSIM PQKKNPDVAE ITRAKLSTLN
GELVTVLTIM KALPNTYNRD LQEISPHLWK SVYTLIDCIQ MVDGMISTIK VNKERMKENA
EKNYSTATEL ADTLVRECGI AFRMAHGIVG ELVKRSIEEK VEIKEIILEV LEKNNLSLSQ
EKIDTALDPF ENVKLRNVIG GPAPEEVERA ISSFNTKIST HKEKLDEKIA EVNTVNKNLL
K