ID   ARLY_METMP              Reviewed;         481 AA.
AC   O74026;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2004, sequence version 2.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE            Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE            EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE   AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN   Name=argH {ECO:0000255|HAMAP-Rule:MF_00006}; OrderedLocusNames=MMP0013;
OS   Methanococcus maripaludis (strain S2 / LL).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=267377;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10220900; DOI=10.1111/j.1574-6968.1999.tb13507.x;
RA   Cohen-Kupiec R., Kupiec M., Sandbeck K., Leigh J.A.;
RT   "Functional conservation between the argininosuccinate lyase of the
RT   archaeon Methanococcus maripaludis and the corresponding bacterial and
RT   eukaryal genes.";
RL   FEMS Microbiol. Lett. 173:231-238(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S2 / LL;
RX   PubMed=15466049; DOI=10.1128/jb.186.20.6956-6969.2004;
RA   Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J.,
RA   Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M.,
RA   Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A.,
RA   Moore B.C., Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D.,
RA   Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W.,
RA   Olson M.V., Leigh J.A.;
RT   "Complete genome sequence of the genetically tractable hydrogenotrophic
RT   methanogen Methanococcus maripaludis.";
RL   J. Bacteriol. 186:6956-6969(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC         Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC         ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00006};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC       from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC       Rule:MF_00006}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR   EMBL; Y16584; CAA76302.1; -; Genomic_DNA.
DR   EMBL; BX950229; CAF29569.1; -; Genomic_DNA.
DR   RefSeq; WP_011169957.1; NC_005791.1.
DR   AlphaFoldDB; O74026; -.
DR   SMR; O74026; -.
DR   STRING; 267377.MMP0013; -.
DR   EnsemblBacteria; CAF29569; CAF29569; MMP0013.
DR   GeneID; 2761122; -.
DR   KEGG; mmp:MMP0013; -.
DR   PATRIC; fig|267377.15.peg.13; -.
DR   eggNOG; arCOG01748; Archaea.
DR   HOGENOM; CLU_027272_2_3_2; -.
DR   OMA; KKNPDVF; -.
DR   OrthoDB; 51806at2157; -.
DR   BioCyc; MMAR267377:MMP_RS00095-MON; -.
DR   UniPathway; UPA00068; UER00114.
DR   Proteomes; UP000000590; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR   CDD; cd01359; Argininosuccinate_lyase; 1.
DR   Gene3D; 1.10.275.10; -; 1.
DR   HAMAP; MF_00006; Arg_succ_lyase; 1.
DR   InterPro; IPR029419; Arg_succ_lyase_C.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   PANTHER; PTHR43814; PTHR43814; 1.
DR   Pfam; PF14698; ASL_C2; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; SSF48557; 1.
DR   TIGRFAMs; TIGR00838; argH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase;
KW   Reference proteome.
FT   CHAIN           1..481
FT                   /note="Argininosuccinate lyase"
FT                   /id="PRO_0000137865"
FT   CONFLICT        73
FT                   /note="N -> I (in Ref. 1; CAA76302)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        75..76
FT                   /note="DL -> IF (in Ref. 1; CAA76302)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   481 AA;  54052 MW;  ED96ADBBA6F62D9B CRC64;
     MNILRRGRLG SNVKEDVMKF TTSLEFDKEI FESDILCDIA HTTMLVEQNV ISEENGKKII
     AELKKIAKRG MENLDLDPSL DDIHMVIESE LIKELGEDVA GRMHTGRSRN DEVATDLRLS
     LRKKVLEIIG HLITMEKNML TVSDAHKETL TVGYTHLQQA QPVTFGHQIL SHVSAIERDI
     SRFFDTYNRI NISPLGCGAM ATTGFNLNRK RTKDLLGFYG IIENSMDGVS SRDFIVETMA
     NISMLGTNLS KICEELVVFS SAEFNTIEIA NEYTSTSSIM PQKKNPDVAE ITRAKLSTLN
     GELVTVLTIM KALPNTYNRD LQEISPHLWK SVYTLIDSIQ MVDGMISTVK VNKERMKENA
     EKNYSTATEL ADTLVRECGI AFRMAHGIVG ELVKRSIEEK VEIKEIISEV LEKNNLSLSQ
     EKIDTALDPF ENVKLRNVIG GPAPEEVERA ISSFNEKISA HKDKLDEKIS EIKTAEKNLL
     E