ID   MIA_BOVIN               Reviewed;         130 AA.
AC   Q28038;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Melanoma-derived growth regulatory protein;
DE   AltName: Full=Cartilage-derived retinoic acid-sensitive protein;
DE            Short=CD-RAP;
DE   AltName: Full=Melanoma inhibitory activity protein;
DE   Flags: Precursor;
GN   Name=MIA; Synonyms=CDRAP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8621736; DOI=10.1074/jbc.271.6.3311;
RA   Dietz U.H., Sandell L.J.;
RT   "Cloning of a retinoic acid-sensitive mRNA expressed in cartilage and
RT   during chondrogenesis.";
RL   J. Biol. Chem. 271:3311-3316(1996).
CC   -!- FUNCTION: May function during cartilage development and maintenance.
CC   -!- SUBUNIT: Interacts with FASLG. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Cartilage primordia and cartilage.
CC   -!- INDUCTION: Repressed by retinoic acid.
CC   -!- PTM: May contain two intramolecular disulfide bonds.
CC   -!- SIMILARITY: Belongs to the MIA/OTOR family. {ECO:0000305}.
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DR   EMBL; U51437; AAC48523.1; -; mRNA.
DR   RefSeq; NP_776361.1; NM_173936.2.
DR   AlphaFoldDB; Q28038; -.
DR   SMR; Q28038; -.
DR   STRING; 9913.ENSBTAP00000011964; -.
DR   PaxDb; Q28038; -.
DR   Ensembl; ENSBTAT00000011964; ENSBTAP00000011964; ENSBTAG00000009078.
DR   GeneID; 280857; -.
DR   KEGG; bta:280857; -.
DR   CTD; 8190; -.
DR   VEuPathDB; HostDB:ENSBTAG00000009078; -.
DR   eggNOG; ENOG502S2XN; Eukaryota.
DR   GeneTree; ENSGT00950000182767; -.
DR   HOGENOM; CLU_158739_0_0_1; -.
DR   InParanoid; Q28038; -.
DR   OMA; EVKTDKW; -.
DR   OrthoDB; 1421159at2759; -.
DR   TreeFam; TF332724; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000009078; Expressed in laryngeal cartilage and 100 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030198; P:extracellular matrix organization; IBA:GO_Central.
DR   InterPro; IPR043369; MIA.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR47312; PTHR47312; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Growth factor; Reference proteome; Secreted; SH3 domain;
KW   Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   CHAIN           23..130
FT                   /note="Melanoma-derived growth regulatory protein"
FT                   /id="PRO_0000019027"
FT   DOMAIN          42..112
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   DISULFID        35..40
FT                   /evidence="ECO:0000250"
FT   DISULFID        58..129
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   130 AA;  14354 MW;  95D153161C78E02A CRC64;
     MAWSLVFLGV VLLSAFPGPS AGGRPMPKLA DRKMCADEEC SHPISVAVAL QDYVAPDCRF
     LTIHQGQVVY IFSKLKGRGR LFWGGSVQGD YYGDGAARLG YFPSSIVRED QTLKPAKTDV
     KTDIWDFYCQ