MIA_MOUSE
ID MIA_MOUSE Reviewed; 130 AA.
AC Q61865; O09086; P97495;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2001, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Melanoma-derived growth regulatory protein;
DE AltName: Full=Cartilage-derived retinoic acid-sensitive protein;
DE Short=CD-RAP;
DE AltName: Full=Melanoma inhibitory activity protein;
DE Flags: Precursor;
GN Name=Mia; Synonyms=Cdrap, Mia1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=7923218;
RA Blesch A., Bosserhoff A.-K., Apfel R., Behl C., Hessdoerfer B., Schmitt A.,
RA Jachimczak P., Lottspeich F., Buettner R., Bogdahn U.;
RT "Cloning of a novel malignant melanoma-derived growth-regulatory protein,
RT MIA.";
RL Cancer Res. 54:5695-5701(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=129/Sv;
RX PubMed=9097023;
RX DOI=10.1002/(sici)1097-0177(199704)208:4<516::aid-aja7>3.0.co;2-l;
RA Bosserhoff A.K., Kondo S., Moser M., Dietz U., Copeland N.G., Gilbert D.J.,
RA Jenkins N.A., Buettner R., Sandell L.J.;
RT "Mouse CD-RAP/MIA gene: structure, chromosomal localization, and expression
RT in cartilage and chondrosarcoma.";
RL Dev. Dyn. 208:516-525(1997).
CC -!- FUNCTION: Elicits growth inhibition on melanoma cells in vitro as well
CC as some other neuroectodermal tumors, including gliomas. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with FASLG. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: All malignant melanoma cell lines tested and
CC infrequently in glioma cell lines.
CC -!- PTM: May possess two intramolecular disulfide bonds.
CC -!- SIMILARITY: Belongs to the MIA/OTOR family. {ECO:0000305}.
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DR EMBL; X94322; CAA63983.1; -; mRNA.
DR EMBL; U85612; AAB42082.1; -; Genomic_DNA.
DR EMBL; X97965; CAA66608.1; -; Genomic_DNA.
DR CCDS; CCDS21013.1; -.
DR RefSeq; NP_062267.2; NM_019394.3.
DR AlphaFoldDB; Q61865; -.
DR SMR; Q61865; -.
DR STRING; 10090.ENSMUSP00000114063; -.
DR PhosphoSitePlus; Q61865; -.
DR PaxDb; Q61865; -.
DR PRIDE; Q61865; -.
DR DNASU; 12587; -.
DR Ensembl; ENSMUST00000071986; ENSMUSP00000071876; ENSMUSG00000089661.
DR GeneID; 12587; -.
DR KEGG; mmu:12587; -.
DR UCSC; uc009fvf.2; mouse.
DR CTD; 8190; -.
DR MGI; MGI:109615; Mia.
DR VEuPathDB; HostDB:ENSMUSG00000089661; -.
DR eggNOG; ENOG502S2XN; Eukaryota.
DR GeneTree; ENSGT00950000182767; -.
DR HOGENOM; CLU_158739_0_0_1; -.
DR InParanoid; Q61865; -.
DR OMA; EVKTDKW; -.
DR OrthoDB; 1421159at2759; -.
DR BioGRID-ORCS; 12587; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Mia; mouse.
DR PRO; PR:Q61865; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q61865; protein.
DR Bgee; ENSMUSG00000089661; Expressed in endochondral bone and 119 other tissues.
DR ExpressionAtlas; Q61865; baseline and differential.
DR Genevisible; Q61865; MM.
DR GO; GO:0005576; C:extracellular region; TAS:MGI.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007160; P:cell-matrix adhesion; IMP:MGI.
DR GO; GO:0030198; P:extracellular matrix organization; IMP:MGI.
DR InterPro; IPR043369; MIA.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR47312; PTHR47312; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Growth factor; Reference proteome; Secreted; SH3 domain;
KW Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..130
FT /note="Melanoma-derived growth regulatory protein"
FT /id="PRO_0000019029"
FT DOMAIN 42..112
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DISULFID 35..40
FT /evidence="ECO:0000250"
FT DISULFID 58..129
FT /evidence="ECO:0000250"
FT CONFLICT 112..113
FT /note="TL -> NS (in Ref. 1; CAA63983)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 130 AA; 14593 MW; 16C957459C5BB5F9 CRC64;
MVWSPVLLGI VVLSVFSGPS RADRAMPKLA DWKLCADEEC SHPISMAVAL QDYVAPDCRF
LTIYRGQVVY VFSKLKGRGR LFWGGSVQGG YYGDLAARLG YFPSSIVRED LTLKPGKIDM
KTDQWDFYCQ
