MIA_RAT
ID MIA_RAT Reviewed; 130 AA.
AC Q62946; P97591;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2001, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Melanoma-derived growth regulatory protein;
DE AltName: Full=Cartilage-derived retinoic acid-sensitive protein;
DE Short=CD-RAP;
DE AltName: Full=Melanoma inhibitory activity protein;
DE Flags: Precursor;
GN Name=Mia; Synonyms=Cdrap, Mia1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Mammary gland;
RX PubMed=9364210;
RX DOI=10.1002/(sici)1098-2744(199710)20:2<204::aid-mc7>3.0.co;2-m;
RA Lu J.X., Pei H., Kaeck M., Thompson H.J.;
RT "Gene expression changes associated with chemically induced rat mammary
RT carcinogenesis.";
RL Mol. Carcinog. 20:204-215(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 34-124.
RC TISSUE=Cartilage;
RX PubMed=8621736; DOI=10.1074/jbc.271.6.3311;
RA Dietz U.H., Sandell L.J.;
RT "Cloning of a retinoic acid-sensitive mRNA expressed in cartilage and
RT during chondrogenesis.";
RL J. Biol. Chem. 271:3311-3316(1996).
CC -!- FUNCTION: May function during cartilage development and maintenance.
CC -!- SUBUNIT: Interacts with FASLG. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Cartilage primordia and cartilage.
CC -!- INDUCTION: Repressed by retinoic acid.
CC -!- PTM: May possess two intramolecular disulfide bonds.
CC -!- SIMILARITY: Belongs to the MIA/OTOR family. {ECO:0000305}.
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DR EMBL; U51438; AAC52481.1; -; mRNA.
DR EMBL; U67884; AAB40659.1; -; mRNA.
DR RefSeq; NP_110479.1; NM_030852.2.
DR AlphaFoldDB; Q62946; -.
DR SMR; Q62946; -.
DR STRING; 10116.ENSRNOP00000002050; -.
DR PaxDb; Q62946; -.
DR GeneID; 81510; -.
DR KEGG; rno:81510; -.
DR UCSC; RGD:620883; rat.
DR CTD; 8190; -.
DR RGD; 620883; Mia.
DR VEuPathDB; HostDB:ENSRNOG00000001499; -.
DR eggNOG; ENOG502S2XN; Eukaryota.
DR HOGENOM; CLU_158739_0_0_1; -.
DR InParanoid; Q62946; -.
DR OMA; EVKTDKW; -.
DR OrthoDB; 1421159at2759; -.
DR PRO; PR:Q62946; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000001499; Expressed in pancreas and 14 other tissues.
DR Genevisible; Q62946; RN.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007160; P:cell-matrix adhesion; ISO:RGD.
DR GO; GO:0030198; P:extracellular matrix organization; ISO:RGD.
DR InterPro; IPR043369; MIA.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR47312; PTHR47312; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Growth factor; Reference proteome; Secreted; SH3 domain;
KW Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..130
FT /note="Melanoma-derived growth regulatory protein"
FT /id="PRO_0000019030"
FT DOMAIN 42..112
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DISULFID 35..40
FT /evidence="ECO:0000250"
FT DISULFID 58..129
FT /evidence="ECO:0000250"
FT CONFLICT 46..47
FT /note="MA -> VT (in Ref. 2; AAC52481)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 130 AA; 14536 MW; 5F99149AECF74501 CRC64;
MVCSPVLLGI VILSVFSGLS RADRAMPKLA DRKLCADEEC SHPISMAVAL QDYVAPDCRF
LTIYRGQVVY VFSKLKGRGR LFWGGSVQGD YYGDLAAHLG YFPSSIVRED LTLKPGKVDM
KTDEWDFYCQ
