ID   MIC10_ASHGO             Reviewed;          82 AA.
AC   Q751T2;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=MICOS complex subunit MIC10;
DE   AltName: Full=Mitochondrial inner membrane organizing system protein 1;
GN   Name=MIC10; OrderedLocusNames=AFR743W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC       the mitochondrial inner membrane that plays crucial roles in the
CC       maintenance of crista junctions, inner membrane architecture, and
CC       formation of contact sites to the outer membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}. Note=The C-terminus is
CC       located in the intermembrane space, while the location of the N-
CC       terminus has not been determined yet. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MICOS complex subunit Mic10 family.
CC       {ECO:0000305}.
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DR   EMBL; AE016819; AAS54115.1; -; Genomic_DNA.
DR   RefSeq; NP_986291.1; NM_212427.1.
DR   AlphaFoldDB; Q751T2; -.
DR   STRING; 33169.AAS54115; -.
DR   EnsemblFungi; AAS54115; AAS54115; AGOS_AFR743W.
DR   GeneID; 4622582; -.
DR   KEGG; ago:AGOS_AFR743W; -.
DR   eggNOG; KOG4604; Eukaryota.
DR   HOGENOM; CLU_068905_3_0_1; -.
DR   InParanoid; Q751T2; -.
DR   OMA; SNCRHDL; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0061617; C:MICOS complex; IEA:EnsemblFungi.
DR   GO; GO:0044284; C:mitochondrial crista junction; IEA:EnsemblFungi.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0042407; P:cristae formation; IEA:EnsemblFungi.
DR   InterPro; IPR007512; Mic10.
DR   PANTHER; PTHR21304; PTHR21304; 1.
DR   Pfam; PF04418; DUF543; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..82
FT                   /note="MICOS complex subunit MIC10"
FT                   /id="PRO_0000221637"
FT   TRANSMEM        21..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        44..82
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   82 AA;  8755 MW;  6F401022B885BF9C CRC64;
     MSGQLEVSAP SRSILNDKWD VVLSNLVVKT GLGFGAGVFA SVLFFKRRAF PVWLGVGFGL
     GRGYAEGDAI FRSHAGLRAV RA